The association of proBNPage with manifestations of age-related cardiovascular, physical, and psychological impairment in community-dwelling older adults

Autor: Marco Zoli, Giampaolo Bianchi, Paola Forti, Antonio Muscari, Donatella Magalotti, Paolo Pandolfi
Přispěvatelé: Muscari, Antonio, Bianchi, Giampaolo, Forti, Paola, Magalotti, Donatella, Pandolfi, Paolo, Zoli, Marco
Rok vydání: 2021
Předmět:
Zdroj: GeroScience
ISSN: 2509-2723
2509-2715
DOI: 10.1007/s11357-021-00381-7
Popis: NT-proB-type natriuretic peptide (NT-proBNP) serum concentration can be transformed by simple formulas into proBNPage, a surrogate of biological age strongly associated with chronological age, all-cause mortality, and disease count. This cross-sectional study aimed to assess whether proBNPage is also associated with other manifestations of the aging process in comparison with other variables. The study included 1117 noninstitutionalized older adults (73.1 ± 5.6 years, 537 men). Baseline measurements of serum NT-proBNP, erythrocyte sedimentation rate, hemoglobin, lymphocytes, and creatinine, which have previously been shown to be highly associated with both age and all-cause mortality, were performed. These variables were compared between subjects with and without manifestations of cardiovascular impairment (myocardial infarction (MI), stroke, peripheral artery disease (PAD), arterial revascularizations (AR)), physical impairment (long step test duration (LSTD), walking problems, falls, deficit in one or more activities of daily living), and psychological impairment (poor self-rating of health (PSRH), anxiety/depression, Mini Mental State Examination (MMSE) score
Databáze: OpenAIRE
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