APOE ɛ4 Is Associated with Postprandial Inflammation in Older Adults with Metabolic Syndrome Traits
| Autor: | Silke Crommen, Sarah Egert, Rolf Fimmers, Martin Coenen, Alfredo Ramirez, Yannik Bernd Schönknecht, Birgit Stoffel-Wagner, Peter Stehle |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
Male Apolipoprotein E Blood lipids Diet Mediterranean medicine.disease_cause metabolism [Metabolic Syndrome] postprandial state blood [Lipids] oxidative stress TX341-641 blood [Interleukin-6] Meals Metabolic Syndrome metabolism [Blood Glucose] metabolism [Inflammation] Meal blood [Biomarkers] Cross-Over Studies Nutrition and Dietetics Middle Aged Postprandial Period Lipids methods [Diet High-Fat] Postprandial Cardiovascular Diseases Female lipids (amino acids peptides and proteins) dietary pattern genetics [Metabolic Syndrome] medicine.medical_specialty Genotype blood [Inflammation] Hyperlipidemias Carbohydrate metabolism Diet High-Fat Article blood [Hyperlipidemias] Apolipoproteins E blood [Cardiovascular Diseases] Internal medicine medicine Humans ddc:610 blood [Metabolic Syndrome] Aged Interleukin-6 Nutrition. Foods and food supply business.industry medicine.disease Crossover study Endocrinology Diet Western inflammation apolipoprotein E gene polymorphism genetics [Apolipoproteins E] Metabolic syndrome business Biomarkers Oxidative stress metabolism [Cardiovascular Diseases] Food Science |
| Zdroj: | Nutrients Volume 13 Issue 11 Nutrients 13(11), 3924 (2021). doi:10.3390/nu13113924 Nutrients, Vol 13, Iss 3924, p 3924 (2021) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13113924 |
| Popis: | The apolipoprotein E (APOE) polymorphism impacts blood lipids and biomarkers of oxidation and inflammation, contributing to an isoform-dependent disease risk. We investigated the effect of the APOE genotype on postprandial metabolism after consumption of three different isoenergetic (4200 kJ) meals in older adults with a CVD risk phenotype. In a randomized crossover study, participants with metabolic syndrome traits (APOE E3, n = 39 E4, n = 10 mean age, 70 ± 5 years BMI 31.3 ± 3.0 kg/m2) consumed a Western-like diet high-fat (WDHF), Western-like diet high-carbohydrate (WDHC), or Mediterranean-like diet (MED) meal. Parameters of lipid and glucose metabolism, inflammatory, and oxidative parameters were analyzed in blood samples collected at fasting and 1–5 h postprandially. Data were analyzed by linear mixed models. The magnitude of the IL-6 increase after the WDHF meal was significantly higher in E4 than in E3 carriers (iAUC: E4 = 7.76 vs. E3 = 2.81 pg/mL × h). The time to detect the IL-6 increase was shorter in the E4 group. All meals produced postprandial glycemia, insulinemia, and lipidemia, without differences between the E3 and the E4 groups. IL-1β and oxidized LDL levels did not change postprandially. In conclusion, APOE E4 carriers display increased postprandial inflammation, indicated by higher postprandial IL-6 increase, when compared to non-carriers. |
| Databáze: | OpenAIRE |
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