Combined surgical and chemotherapeutic treatment of Fortner's amelanotic hamster melanoma AMel 3
| Autor: | W. Wohlrab, J. Peker, E. Haneke |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Immunosuppression Therapy
Male Chemotherapy Pathology medicine.medical_specialty business.industry Melanoma medicine.medical_treatment Hamster Dermatology Neoplasms Experimental medicine.disease Vinblastine Tumor recurrence Surgical removal Cricetinae Cancer research Medicine Animals Vincaleucoblastine Female business Surgical treatment |
| Zdroj: | The British journal of dermatology. 87(1) |
| ISSN: | 0007-0963 |
| Popis: | Summary.— Golden hamsters were injected subcutaneously with melanoma cells and treated with vincaleucoblastine (VLB) after growth of the tumour. The prolongation of survival time after surgical removal of the tumour was compared with that of a non-operated, VLB-treated control group. The survival time of the operated hamsters was significantly prolonged. Although they did not show signs of tumour recurrence, 3 operated animals died from the VLB treatment. Comparing the results of both chemotherapy and combined chemotherapeutic and surgical treatment with those of experiments without cytostatic therapy, the markedly unfavourable effect of VLB on hamsters with melanomata is apparent. We suppose the immunosuppressive side-effect of VLB to be responsible for this negative result. |
| Databáze: | OpenAIRE |
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