Effects of Aging on Formalin-Fixed Brain Weight in Mice and Rats

Autor:	Geoffrey M. Clark, Philip C. Truncer, Robert J. Douglas, Charles M. Treneer
Rok vydání:	1981
Předmět:	Neurons Aging medicine.medical_specialty Brain Organ Size Formalin fixed Anatomy Biology Rats Mice Endocrinology Formaldehyde Internal medicine medicine Animals Tissue Preservation Geriatrics and Gerontology Brain weight Brain aging
Zdroj:	Gerontology. 27:127-132
ISSN:	1423-0003 0304-324X
DOI:	10.1159/000212460
Popis:	In three mouse lineages it was found that during the 18- to 60-day interval after formalin fixation, brain weight was inversely proportional to the age at sacrifice, as was the decline in the weight of the brain during this period. In a second study using rat subjects it was confirmed that the aging difference is due to a reduction, in old age, of the swelling reaction of the brain when first placed in a formalin solution. It was suggested that this easily measured phenomenon might be employed as an operational index of brain aging.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::163db8195ce672b4eb4f4aa47b3caef2 https://doi.org/10.1159/000212460 Zobrazit plný text záznamu