Comparison of 68Ga-DOTA-Siglec-9 and 18F-Fluorodeoxyribose-Siglec-9: Inflammation Imaging and Radiation Dosimetry
| Autor: | Sanna Hellberg, Riikka Siitonen, Mia Ståhle, Juhani Knuuti, Meeri Käkelä, Sirpa Jalkanen, Johanna M. U. Silvola, Xiang-Guo Li, Kerttuli Helariutta, Anne Roivainen, Tuula Tolvanen, Heidi Liljenbäck, Helena E. Virtanen, Anu Autio, Antti Saraste, Tibor Z. Veres, Anu J. Airaksinen |
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| Přispěvatelé: | Department of Chemistry, Tracers in Molecular Imaging (TRIM) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty lcsh:Medical technology Article Subject 116 Chemical sciences Inflammation VASCULAR ADHESION PROTEIN-1 MOUSE 030218 nuclear medicine & medical imaging 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Inflammation imaging medicine Dosimetry DOTA Radiology Nuclear Medicine and imaging PEPTIDE neoplasms ATHEROSCLEROTIC PLAQUES SIGLEC-9 ta3126 biology business.industry Lectin SIGLEC Pet imaging Muscle inflammation respiratory system 3. Good health 030104 developmental biology chemistry lcsh:R855-855.5 317 Pharmacy biology.protein medicine.symptom business |
| Zdroj: | Contrast Media & Molecular Imaging, Vol 2017 (2017) |
| ISSN: | 1555-4309 |
| DOI: | 10.1155/2017/7645070 |
| Popis: | Sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) is a ligand of inflammation-inducible vascular adhesion protein-1 (VAP-1). We compared 68Ga-DOTA- and 18F-fluorodeoxyribose- (FDR-) labeled Siglec-9 motif peptides for PET imaging of inflammation. Methods. Firstly, we examined 68Ga-DOTA-Siglec-9 and 18F-FDR-Siglec-9 in rats with skin/muscle inflammation. We then studied 18F-FDR-Siglec-9 for the detection of inflamed atherosclerotic plaques in mice and compared it with previous 68Ga-DOTA-Siglec-9 results. Lastly, we estimated human radiation dosimetry from the rat data. Results. In rats, 68Ga-DOTA-Siglec-9 (SUV, 0.88±0.087) and 18F-FDR-Siglec-9 (SUV, 0.77±0.22) showed comparable (P=0.29) imaging of inflammation. In atherosclerotic mice, 18F-FDR-Siglec-9 detected inflamed plaques with a target-to-background ratio (1.6±0.078) similar to previously tested 68Ga-DOTA-Siglec-9 (P=0.35). Human effective dose estimates for 68Ga-DOTA-Siglec-9 and 18F-FDR-Siglec-9 were 0.024 and 0.022 mSv/MBq, respectively. Conclusion. Both tracers are suitable for PET imaging of inflammation. The easier production and lower cost of 68Ga-DOTA-Siglec-9 present advantages over 18F-FDR-Siglec-9, indicating it as a primary choice for clinical studies. |
| Databáze: | OpenAIRE |
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