Nanoceutical Fabric Prevents COVID-19 Spread through Expelled Respiratory Droplets: A Combined Computational, Spectroscopic, and Antimicrobial Study
| Autor: | Uttam Pal, Sayan Bayan, Ria Ghosh, Tanusri Saha-Dasgupta, Samir Kumar Pal, Soumendra Darbar, Susmita Mondal, Aniruddha Adhikari, Samit K. Ray |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Biomedical Engineering chemistry.chemical_element Zinc Article Nanomaterials Biomaterials chemistry.chemical_compound Anti-Infective Agents Bacterial Proteins Humans Denaturation (biochemistry) Recycling Cotton Fiber SARS-CoV-2 mimic Cellulose ZnO nanoflower self-cleaning PPE SARS-CoV-2 Biochemistry (medical) Masks antimicrobial fabric COVID-19 Respiratory Aerosols and Droplets General Chemistry Nanoflower Antimicrobial nanoceutical Nanostructures Face masks Chemical engineering chemistry Pseudomonas aeruginosa Spike Glycoprotein Coronavirus Zinc Oxide |
| Zdroj: | ACS Applied Bio Materials |
| ISSN: | 2576-6422 |
| Popis: | Centers for Disease Control and Prevention (CDC) warns the use of one-way valves or vents in free masks for potential threat of spreading COVID-19 through expelled respiratory droplets. Here, we have developed a nanoceutical cotton fabric duly sensitized with non-toxic zinc oxide nanomaterial for potential use as membrane filter in the one way valve for the ease of breathing without the threat of COVID-19 spreading. A detailed computational study revealed that zinc oxide nanoflowers (ZnO NF) with almost two-dimensional petals trap SARS-CoV-2 spike proteins, responsible to attach to ACE-2 receptors in human lung epithelial cells. The study also confirm significant denaturation of the spike proteins on the ZnO surface, revealing removal of virus upon efficient trapping. Following the computational study, we have synthesized ZnO NF on cotton matrix using hydrothermal assisted strategy. Electron microscopic, steady-state and picosecond resolved spectroscopic studies confirm attachment of ZnO NF to the cotton (i.e., cellulose) matrix at atomic level to develop the nanoceutical fabric. A detailed antimicrobial assay using Pseudomonas aeruginosa bacteria (model SARS-CoV-2 mimic) reveals excellent anti-microbial efficiency of the developed nanoceutical fabric. To our understanding the novel nanoceutical fabric used in one-way valve of a face mask would be the choice to assure breathing comfort along with source control of COVID-19 infection. The developed nanosensitized cloth can also be used as antibacterial/anti CoV-2 washable dress material in general.GRAPHICAL ABSTRACTA novel nanoceutical cotton fabric duly sensitized with non-toxic zinc oxide nanoflower can potentially be used as membrane filter in the one way valve of face mask to assure breathing comfort along with source control of COVID-19 infection. The nanoceutical fabric denatures the SARS-CoV-2 spike protein and makes the microorganism ineffective. |
| Databáze: | OpenAIRE |
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