Technical performance of shear wave elastography for measuring liver stiffness in pediatric and adolescent patients: a systematic review and meta-analysis
Autor: | Jin Seong Lee, Ah Young Jung, Dong Wook Kim, Chan Park, Hee Mang Yoon, Young Ah Cho, Seung Chai Jung |
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Rok vydání: | 2018 |
Předmět: |
Liver Cirrhosis
medicine.medical_specialty Blinding Adolescent 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Liver stiffness medicine Humans Radiology Nuclear Medicine and imaging Child Shear wave elastography business.industry Significant difference Reproducibility of Results General Medicine Random effects model Elasticity Technical performance Liver 030220 oncology & carcinogenesis Meta-analysis Elasticity Imaging Techniques Radiology business Transient elastography |
Zdroj: | European radiology. 29(5) |
ISSN: | 1432-1084 |
Popis: | To assess the technical performance (proportion of technical failure and unreliable measurements) of shear wave elastography (SWE) for assessing liver stiffness in pediatric and adolescent patients. We searched Ovid-MEDLINE and EMBASE databases for eligible studies and selected original articles investigating transient elastography (TE), point shear wave elastography (pSWE), or two-dimensional SWE (2D-SWE) for measuring liver stiffness in pediatric and adolescent patients. A quantitative synthesis of studies reporting technical failures and/or unreliable measurements of TE, pSWE, or 2D-SWE is presented. Meta-analytic pooling was conducted using the random effects model. Meta-regression analysis was conducted to explore potential causes of heterogeneity. Forty of 69 studies (58%) provided technical performance information. Technical failure data were reported in 3 TE, 6 pSWE, and 8 2D-SWE studies. Unreliable measurement data were provided in 21 TE, 4 pSWE, and 1 2D-SWE study. The pooled proportion of unreliable measurements of TE was 12.1%. Meta-regression analysis showed that the study population size and readers’ blinding to pathologic results affected the study’s heterogeneity. The pooled proportions of technical failure during pSWE and 2D-SWE were 4.1% and 2.2%, respectively, demonstrating no significant difference between the techniques. We reviewed the technical performance of SWE, especially the rate of unreliable measurements from TE studies and rates of technical failure from pSWE and 2D-SWE studies. Considering the importance of technical performance for clinical validation of SWE, numbers of and reasons for technical failure and unreliable measurements should be reported in future studies. Further efforts are necessary to standardize SWE reliability criteria. • Most TE studies reported rate of unreliable measurements, whereas pSWE and 2D-SWE studies were likely to report rates of technical failure. • The pooled proportion of unreliable measurements of TE was 12.1%. • The pooled proportions of technical failure during pSWE and 2D-SWE were 4.1% and 2.2%, respectively, demonstrating no significant difference between the techniques. |
Databáze: | OpenAIRE |
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