Analysis of induced error by susceptibility effect in low-density gel dosimeters
| Autor: | Ehsan Eqlimi, Mona Mirheydari, Farideh Pak, Vahid Vaezzadeh |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Materials science Diffusion Analytical chemistry Radiation Dosage lcsh:RC254-282 mathematical analysis Dose mapping 03 medical and health sciences 0302 clinical medicine inaccuracy low-density gel dosimeter Low density Humans Radiology Nuclear Medicine and imaging Dosimeter Radiation Dosimeters Spatially resolved General Medicine Models Theoretical lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Expanded polystyrene Magnetic Resonance Imaging Magnetic field susceptibility effect 030104 developmental biology Oncology Relaxation rate 030220 oncology & carcinogenesis SPHERES Radiotherapy Conformal Gels Algorithms |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 15, Iss 3, Pp 498-503 (2019) |
| ISSN: | 1998-4138 |
| Popis: | Purpose: In low-density (LD) gel dosimeter, diffusive spin–spin relaxation rate (R2)-dispersion caused by susceptibility-induced internal gradient leads to a significant deviation in the measured R2 from the real value. In this study, the effect of induced internal gradient on R2 was visualized and quantified algebraically as an important cause of inaccuracy in LD gel dosimeters. Materials and Methods: In this method, two sets of LD and unit-density (UD) gel dosimeters were prepared. The LD gel was made by mixing the UD gel with expanded polystyrene spheres. The R2 was used to determine the spatially resolved decay rates due to diffusion in internal magnetic field. The internal gradient was calculated for a multiple spin–echo sequence. Results: It is shown that in a LD gel, the internal gradient leads to overestimation of mean R2 value (R2mean). Pixel-by-pixel R2 measurements inside a LD gel showed significant deviation from R2 mapping in UD gel. Conclusion: It appears that significant differences between R2mean in a selected region of interest and pixel-by-pixel R2 values are the main source of inaccuracy in dose mapping of a LD gel. |
| Databáze: | OpenAIRE |
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