Filament heterogeneity within the dystrophic neurites of senile plaques suggests blockage of fast axonal transport in Alzheimer's disease
| Autor: | P. L. Richey, Mark A. Smith, Darja Praprotnik, George Perry, Harry V. Vinters |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Neurofilament macromolecular substances Biology Axonal Transport Pathology and Forensic Medicine Amyloid beta-Protein Precursor Cellular and Molecular Neuroscience Degenerative disease Alzheimer Disease Neurites medicine Humans Senile plaques Axon Microscopy Immunoelectron Cytoskeleton Aged Aged 80 and over Dystrophy Neurofibrillary Tangles Middle Aged medicine.disease Immunohistochemistry Actin Cytoskeleton medicine.anatomical_structure Axoplasmic transport Neurology (clinical) Alzheimer's disease |
| Zdroj: | Acta Neuropathologica. 91:226-235 |
| ISSN: | 1432-0533 0001-6322 |
| DOI: | 10.1007/s004010050420 |
| Popis: | In this study, the direct comparison of biopsy and autopsy tissue by morphological and immunocytochemical techniques, respectively, was used to document cytoskeletal changes of dystrophic neurites (DN) of senile plaques in Alzheimer's disease. This dual approach demonstrated several unreported abnormalities which, together with analogous findings in several experimental models, suggest that DN are associated with deficiencies in fast axonal transport and replacement of the cytoskeleton by an array of related abnormal filaments. |
| Databáze: | OpenAIRE |
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