Association between low C-peptide and fragility fractures in postmenopausal women without diabetes
| Autor: | Carmine Gazzaruso, Sandro Giannini, Massimiliano Marco Corsi Romanelli, Adriana Coppola, Mariangela Fodaro, V. Zambianchi, Pietro Gallotti, M. Marazzi, Arturo Pujia, Diego Russo, Cristina Russo, Tiziana Montalcini, Yvelise Ferro, Stefano Romeo, Emanuela Galliera |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Inverse Association Bone density Endocrinology Diabetes and Metabolism Osteoporosis 030209 endocrinology & metabolism Logistic regression 03 medical and health sciences 0302 clinical medicine Endocrinology Lumbar Bone Density Risk Factors Diabetes mellitus Internal medicine Diabetes Mellitus Prevalence medicine Humans Osteoporosis Postmenopausal Aged Bone mineral C-Peptide business.industry Diabetes Middle Aged Prognosis medicine.disease Postmenopausal women Postmenopause Cross-Sectional Studies 030104 developmental biology Italy Cohort Fractures Female business Biomarkers Osteoporotic Fractures Follow-Up Studies |
| Zdroj: | Journal of Endocrinological Investigation. 40:1091-1098 |
| ISSN: | 1720-8386 |
| DOI: | 10.1007/s40618-017-0672-4 |
| Popis: | C-peptide has been shown to exert several, previously unknown, biological effects. A recent cross-sectional study demonstrated an association between low C-peptide serum levels and low lumbar bone density of postmenopausal women not affected by diabetes. To date, very little research attention has been directed toward the association between C-peptide and osteoporotic fractures. To contribute toward filling this gap, we investigated the association between C-peptide and fractures in postmenopausal women. A cohort of 133 non-diabetic postmenopausal women with and without a history of fractures was evaluated in this cross-sectional investigation. Standardized interviews were performed to gather information on the patients’ fracture history. All of the participants underwent a bone mineral density assessment by DXA, radiographs, and a serum C-peptide measurement. Thirty-four women presented fractures. Bivariate analysis revealed an inverse correlation between C-peptide and fractures (r = −0.27, p = 0.002). A significant difference in mean C-peptide levels was also found between women with vs. without fractures (p = 0.01, adjusted for age, BMI and glucose). Logistic regression analysis showed that C-peptide levels, femoral and vertebral BMD were all negatively associated with fracture status (B = −1.097, ES = 0.401, p = 0.006, 95% CI 0.15–0.73; B = −15.6, SE = 4.17, p |
| Databáze: | OpenAIRE |
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