The influence of type 2 diabetes on fibrin structure and function
| Autor: | Robert A. S. Ariëns, Emma J. Dunn, Peter J. Grant |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Population Type 2 diabetes Fibrinogen Fibrin Body Mass Index Reference Values Risk Factors Glycation Diabetes mellitus Internal medicine Fibrinolysis Internal Medicine medicine Body Size Humans Hypoglycemic Agents education Blood Coagulation education.field_of_study Factor XIII biology business.industry Middle Aged medicine.disease Lipids Endocrinology Diabetes Mellitus Type 2 Cardiovascular Diseases biology.protein Female business Body mass index Diabetic Angiopathies medicine.drug |
| Zdroj: | Diabetologia. 48:1198-1206 |
| ISSN: | 1432-0428 0012-186X |
| DOI: | 10.1007/s00125-005-1742-2 |
| Popis: | The precise mechanisms underlying the increased risk of cardiovascular disease (CVD) in type 2 diabetes are unclear. Fibrin clot structure has been related to CVD risk in the general population. We therefore assessed this in type 2 diabetic patients as a potential mechanism whereby diabetes influences CVD risk. Fibrin clots were formed from fibrinogen purified from 150 subjects with type 2 diabetes and varying degrees of glycaemic control (assessed by HbA1c), and from 50 matched control subjects. Clot structure was assessed by turbidity, permeation and confocal microscopy. The specific effect of glucose itself was assessed by analysing the structure of clots formed from purified fibrinogen in the presence of increasing concentrations of the sugar. Clots formed by fibrinogen purified from type 2 diabetic subjects had a denser, less porous structure than those from control subjects. The structural changes found were related to the individual’s glycaemic control; HbA1c correlated negatively with permeation coefficient (K s) values (indicates clot pore size) (r=−0.57, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink