Time-course of blood acid-base state during arousal from hibernation in the European hamster
| Autor: | André Malan, C Calgari, E. Mioskowski |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Hibernation
Acid-Base Equilibrium medicine.medical_specialty Physiology Acid–base homeostasis Biology medicine.disease Biochemistry pCO2 Respiratory acidosis Endocrinology Internal medicine Cricetinae Hyperventilation medicine Arterial blood Animals Animal Science and Zoology medicine.symptom Respiratory system Arousal Ecology Evolution Behavior and Systematics Acidosis |
| Zdroj: | Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 158(4) |
| ISSN: | 0174-1578 |
| Popis: | 1. Arterial blood was sampled at 15 min-intervals in European hamsters Cricetus cricetus fitted with indwelling catheters, from deep hibernation to full arousal. Temperature-corrected pH and PCO2, respectively pH* and P*CO2, were directly measured at 37 degrees C. 2. Deep hibernation corresponded to a respiratory acidosis: pH* = 7.01 +/- 0.01 (mean +/- SE), P*CO2 = 160 +/- 4 Torr (n = 9 animals). 3. Three periods could be distinguished in the arousal: (i) a period of hyperventilation (28 +/- 5 min), in which P*CO2 was reduced to 79 +/- 4 Torr, while cheek pouch temperature increased only by 0.9 +/- 0.2 degrees C; (ii) a period of metabolic acidification by lactate accumulation (84 +/- 6 min), corresponding to the period of peak thermogenesis; (iii) a progressive return to euthermic conditions (104 +/- 10 min), by simultaneous respiratory and metabolic alkalinization. 4. Over 60% of the blood CO2 stores accumulated at the beginning of the hibernation bout were released by hyperventilation during the first period, prior to the full development of thermogenesis. This is in agreement with the hypothesis of an inhibitory role of the respiratory acidosis in hibernation. |
| Databáze: | OpenAIRE |
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