Multicenter collaborative evaluation of a standardized serum bactericidal test as a predictor of therapeutic efficacy in acute and chronic osteomyelitis
| Autor: | Alexander Ackley, Charles W. Stratton, H. Bradford Hawley, Melvin P. Weinstein, L. Barth Reller |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
medicine.medical_specialty
Blood Bactericidal Activity medicine.medical_treatment Indicator Dilution Techniques Gastroenterology Incubation period Serum Bactericidal Test Internal medicine medicine Humans Prospective Studies Chemotherapy business.industry Osteomyelitis General Medicine Bacterial Infections Antimicrobial medicine.disease Prognosis Anti-Bacterial Agents Titer Chronic osteomyelitis Evaluation Studies as Topic Immunology Acute Disease Chronic Disease Drug Therapy Combination Osteitis business |
| Zdroj: | The American journal of medicine. 83(2) |
| ISSN: | 0002-9343 |
| Popis: | Forty-eight episodes of osteomyelitis, 30 acute and 18 chronic, were evaluated in a prospective multicenter collaborative study to determine whether a standardized serum bactericidal test could predict outcome of infection. All centers used a microdilution test method that defined the recognized important test variables, including inoculum size, culture medium, dilution technique, incubation time, method of subculture, and bactericidal endpoint. In patients with acute osteomyelitis, peak serum bactericidal titers had no predictive value; however, trough titers of 1:2 or greater accurately predicted cure, whereas trough titers of less than 1:2 predicted therapeutic failure. In patients with chronic osteomyelitis, peak serum bactericidal titers of 1:16 or greater and trough titers of 1:4 or greater accurately predicted cure, whereas peak titers of less than 1:16 and trough titers of less than 1:2 accurately predicted failure. It is concluded that this standardized serum bactericidal test provides good prognostic information in patients with osteomyelitis, and it is recommended that patients with acute osteomyelitis have serum bactericidal titers of 1:2 or greater at all times and that patients with chronic osteomyelitis have serum bactericidal titers of 1:4 or greater at all times. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|