Anthropological analyses of 30 insertion/deletion autosomal markers in five major ethnic groups of Pakistan
| Autor: | Claus Børsting, Rebecca Røgen, Muhammad Adnan Shan, Niels Morling, Julie Mechlenborg |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
forensic sciences
Ethnic group individual identification Population genetics Biology Biochemistry Genetics and Molecular Biology (miscellaneous) Pathology and Forensic Medicine Analytical Chemistry qiagen investigator DIPplex kit Qiagen Insertion deletion anthropology Physical and Theoretical Chemistry Indel Genetics forensic genetics K5000-5582 investigator® dipplex kit population genetics food and beverages Criminal law and procedure Forensic science Psychiatry and Mental health Anthropology Forensic sciences Public aspects of medicine RA1-1270 Forensic genetics |
| Zdroj: | Forensic Sciences Research, Vol 0, Iss 0, Pp 1-5 (2021) Shan, M A, Mechlenborg, J, Røgen, R, Børsting, C & Morling, N 2022, ' Anthropological analyses of 30 insertion/deletion autosomal markers in five major ethnic groups of Pakistan ', Forensic Sciences Research, vol. 7, no. 2, pp. 202-206 . https://doi.org/10.1080/20961790.2021.1933366 |
| ISSN: | 2471-1411 2096-1790 |
| DOI: | 10.1080/20961790.2021.1933366 |
| Popis: | We investigated the forensic efficacy of the 30 insertion/deletion (Indel) markers included in the Qiagen Investigator® DIPplex kit in 529 Pakistani individuals from five major subpopulations in Pakistan (Punjabi, Pashtun, Sindhi, Saraiki, and Baloch). In the Sindhi population, the distribution of HLD81 and HLD97 alleles deviated from Hardy-Weinberg equilibrium after Bonferroni correction. The combined match probability ranged from 2.0E-12 (Pashtun and Baloch) to 1.0E-12 (Sindhi), and the mean paternity exclusion power varied from 0.995 (Punjabi, Sindhi, and Saraiki) to 0.996 (Pashtun and Baloch). The high combined power of discrimination (0.999 999 999 999 97) and low combined match probability (1.7E-12) for all subpopulations studied support the utility of the 30 Indel markers for forensic identification in the studied subpopulations. The allele frequencies of the Indel markers in the Pakistani subpopulations were compared with those from 18 other populations. The results show that the populations clustered according to geography. The subpopulations investigated in this work showed a close genetic relationship with others from Pakistan, as well as with South Central Asian and Middle Eastern populations. The results suggest that the Investigator® DIPplex kit can be useful as a supplementary tool for human identification in the five Pakistani subpopulations investigated in this study. Supplemental data for this article is available online at https://doi.org/10.1080/20961790.2021.1933366. |
| Databáze: | OpenAIRE |
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