Immune-endocrine interactions in treated and untreated cats naturally infected with FIV
| Autor: | Graciela Mira, María Amelia Gisbert, Adriana Fontanals, N.V. Gómez, Víctor Castillo, María Fernanda Cabrera Blatter, Paola B. Pisano |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Feline immunodeficiency virus medicine.medical_specialty Thyroid Hormones Hydrocortisone Immunology Adrenocorticotropic hormone Immunodeficiency Virus Feline Antiviral Agents Interleukin-23 Immune system Adrenocorticotropic Hormone Internal medicine Feline Acquired Immunodeficiency Syndrome medicine Endocrine system Animals CATS General Veterinary biology business.industry Viral Load biology.organism_classification Interleukin-12 Hypothalamic–pituitary–thyroid axis Interleukin-10 Endocrinology Lentivirus Cats Female business Viral load Zidovudine |
| Zdroj: | Veterinary immunology and immunopathology. 143(3-4) |
| ISSN: | 1873-2534 |
| Popis: | Feline immunodeficiency virus (FIV) is a lentivirus that causes a progressive disruption of immune function in cats. The neuroendocrine and immune systems communicate bidirectionally, mediated by cytokines such as tumour necrosis factor-α (TNF), several interleukins (IL-1, IL-6, IL-10), and through signals induced by the ratio of IL-10 to IL-12. FIV can affect both pituitary adrenal and thyroid axis function. Twenty FIV-infected cats in similar stages of the disease were evaluated for six months. A cross-sectional study in which the twenty cats were divided into two groups was performed. Ten were treated with Zidovudine (ZDV: 5mg/kg/d, PO, q12h, for six months) and 10 were untreated. Plasma concentrations of adrenocorticotropic hormone (ACTH), cortisol, T4, FT4, T3, IL-10, IL-12 and viral load (VL) were evaluated after six months. ACTH was found in significantly lower concentrations (p0.0001) in the treated group whereas cortisol did not show significant differences between the two groups. Both T4 and FT4 had high values in untreated individuals (p0.001) compared with Zidovudine treated cats. T3 did not show significant differences between the two groups. Both IL-10 and IL-12 were found in significantly higher concentrations in ZDV treated cats (p0.001). By contrast, the IL10/IL-12 ratio values were significantly lower in untreated cats. Viral load was significantly lower in the treated cats after six months of therapy, compared with values detected pre-treatment (p0.002). Untreated cats showed a significant increase of VL (p0.04) compared with the values at the beginning of the study. In treated cats, VL showed lower numbers of viral copies than in untreated cats (p0.01). In summary, Zidovudine treatment appeared to contribute to the normalization of both the adrenal and thyroid axes. This effect could be attributed to the decrease observed in VL, resulting in a change in cytokine patterns. |
| Databáze: | OpenAIRE |
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