Retrograde Radioisotope Myocardial Perfusion Patterns in Dogs
| Autor: | Harper K. Hellems, James R. Galyean, Angel K. Markov, Anthony A. Cibulski, Robert O. Smith, William M. Flowers, Patrick H. Lehan |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Myocardial ischemia
Heart Ventricles medicine.medical_treatment Blood Pressure Coronary Disease In Vitro Techniques Veins Dogs Heart Rate Coronary Circulation Physiology (medical) Methods Animals Medicine Cardiac Output Radionuclide Imaging Partial closure Saline Coronary sinus Radioisotopes Coronary Vein business.industry Myocardium Hemodynamics Krypton Heart Myocardial imaging Coronary Vessels Perfusion Injections Intravenous Potassium Isotopes Cardiology and Cardiovascular Medicine business Nuclear medicine Ischemic heart |
| Zdroj: | Circulation. 50:159-166 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.cir.50.1.159 |
| Popis: | A retrograde coronary vein injection technique for concentrating radioisotope in ischemic myocardial regions was evaluated in dogs. Potassium-43 in saline solution was injected into the coronary veins during complete closure of the coronary sinus. In the presence of coronary inflow obstruction, the venous potassium-43 was distributed mainly to the low pressure vessels in ischemic heart regions; i.e., the ratio of potassium-43 in the occluded-to-unoccluded areas ranged from 2:1 to 3:1 thirty seconds after retrograde injections. Krypton-85 in saline solution was injected under pressure into the coronary veins during partial closure of the coronary sinus. In the presence of inflow obstruction, the ratio of krypton-85 in the occluded- to-unoccluded areas ranged from 4:1 to 6:1 sixty seconds after retrograde injections; larger ratios may be expected after rapid washout of gas from the normally perfused region is nearly complete. Myocardial potassium-43 imaging techniques were applied to locate and measure the size of the ischemic heart region as a radioisotopic hot spot. Detection of hypoperfused areas of extremely small size may be accomplished by this technique. |
| Databáze: | OpenAIRE |
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