Maturation of the microglial population varies across mesolimbic nuclei
| Autor: | Isobel A. Hawes, Lindsay M. De Biase, Keenan T. Hope, Eric N. Moca, Antonello Bonci |
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| Rok vydání: | 2019 |
| Předmět: |
Programmed cell death
Phagocytosis Population Nucleus accumbens Biology Basal Ganglia Nucleus Accumbens 03 medical and health sciences Mice 0302 clinical medicine Lysosome Basal ganglia medicine Animals education 030304 developmental biology 0303 health sciences education.field_of_study Microglia General Neuroscience Ventral Tegmental Area Brain Cell biology Ventral tegmental area medicine.anatomical_structure 030217 neurology & neurosurgery |
| Zdroj: | The European journal of neuroscienceREFERENCES. 52(7) |
| ISSN: | 1460-9568 |
| Popis: | Microglia play critical roles during CNS development and undergo dramatic changes in tissue distribution, morphology, and gene expression as they transition from embryonic to neonatal to adult microglial phenotypes. Despite the magnitude of these phenotypic shifts, little is known about the time course and dynamics of these transitions and whether they vary across brain regions. Here, we define the time course of microglial maturation in key regions of the basal ganglia in mice, where significant regional differences in microglial phenotype are present in adults. We found that microglial density peaks in the ventral tegmental area (VTA) and nucleus accumbens (NAc) during the third postnatal week, driven by a burst of microglial proliferation. Microglial abundance is then refined to adult levels through a combination of tissue expansion and microglial programmed cell death. This overproduction and refinement of microglia was significantly more pronounced in the NAc than in the VTA and was accompanied by a sharp peak in NAc microglial lysosome abundance in the third postnatal week. Collectively, these data identify a key developmental window when elevated microglial density in discrete basal ganglia nuclei may support circuit refinement and could increase susceptibility to inflammatory insults. |
| Databáze: | OpenAIRE |
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