Cardiac inotropic effects of ethanol and calcium-channel modulators
| Autor: | Robert G. Carpentier, Adriana Gallardo-Carpentier, Robert L. Isaacson, Raul P. Salvatici |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Inotrope Dihydropyridines medicine.medical_specialty Health (social science) Liquid diet chemistry.chemical_element Stimulation In Vitro Techniques Calcium Toxicology Biochemistry Contractility Behavioral Neuroscience chemistry.chemical_compound Internal medicine medicine Animals Drug Interactions Nimodipine Ethanol Chemistry Calcium channel Rats Inbred Strains General Medicine 3-Pyridinecarboxylic acid 1 4-dihydro-2 6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)- Methyl ester Myocardial Contraction Stimulation Chemical Rats Endocrinology Neurology Calcium Channels medicine.drug |
| Zdroj: | Alcohol. 9:293-297 |
| ISSN: | 0741-8329 |
| DOI: | 10.1016/0741-8329(92)90069-m |
| Popis: | Our objective was to analyze the influence of ethanol ingestion on the in vitro inotropic effects of dihydropyridines alone, or in combination with ethanol, on atrial muscle from rats offered a liquid diet with ethanol ("ethanol rats," ER) or without ethanol ("normal rats," NR). Left atria from NR or ER were superfused with Tyrode's solution (36 degrees C) and driven at 1.5 Hz while recording tension. Bay K 8644 (BAYK) increased, while nimodipine or ethanol decreased, the tension developed and the velocity of development of tension. The preparations recovered rapidly from the effects of ethanol, but not from those of the dihydropyridines. The effects of ethanol and dihydropyridines in combination were the result of the additive or counteractive actions of the drugs. The effects of ethanol and nimodipine on ER preparations were not different from those observed in NR. The action of BAYK was significantly smaller in ER than in NR. In other words, chronic ingestion of ethanol reduced the positive inotropic effect of BAYK, but it did not modify the negative inotropic action of nimodipine or ethanol. |
| Databáze: | OpenAIRE |
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