Quantification of stromal reaction in breast carcinoma and its correlation with tumor grade and free progression survival

Autor: Michel Jondet, Philippe Simon, Jean Christophe Noël, Michel Vanhaeverbeek, Xavier Catteau
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Psychologie appliquée
Cancer Treatment
0302 clinical medicine
Animal Cells
Breast Tumors
Tumor Microenvironment
Medicine and Health Sciences
Myofibroblasts
Connective Tissue Cells
Aged
80 and over
Multidisciplinary
Invasive Tumors
Carcinoma
Ductal
Breast
Sciences bio-médicales et agricoles
Middle Aged
Gene Expression Regulation
Neoplastic
Oncology
Invasive carcinoma of no special type
Connective Tissue
030220 oncology & carcinogenesis
Disease Progression
Medicine
Female
Anatomy
Cellular Types
Breast carcinoma
Biologie
Research Article
Adult
Stromal cell
Histology
Imaging Techniques
Science
Breast Neoplasms
Image Analysis
Research and Analysis Methods
Carcinomas
Lymphatic System
03 medical and health sciences
Breast cancer
medicine
Carcinoma
Humans
Aged
Retrospective Studies
Tumor microenvironment
business.industry
Cancer
Biology and Life Sciences
Cancers and Neoplasms
Cell Biology
Fibroblasts
medicine.disease
Survival Analysis
Actins
030104 developmental biology
Biological Tissue
Tumor progression
Cancer research
Lymph Nodes
Neoplasm Grading
Stromal Cells
business
Zdroj: PLoS ONE, Vol 14, Iss 3, p e0210263 (2019)
PLoS ONE
PloS one, 14 (3
ISSN: 1932-6203
Popis: Cancer progression results from a complex interplay between tumor cells and the extracellular milieu. In breast carcinoma, the stromal microenvironment has been suggested to play a major role in promoting tumor growth, progression, and invasion. The stroma of 154 resected specimens of invasive breast carcinoma of no special type was quantified using a digital image analyzer. Statistical analyses were performed between the quantity of stroma and survival, as well as between progression-free survival and clinicopathological data. Levels of myofibroblastic stroma varied from 0–46%, with a median of 15.1% and a standard deviation of 7.5. The myofibroblastic stromal reaction was statistically greater in grade 2 and 3 tumors (p = 0.029). Furthermore, there was a trend for worse progression-free survival in the group of node-negative tumors with strong smooth-muscle actin stromal expression (Log rank = 0.075). The present study demonstrates that the myofibroblastic reaction of breast invasive carcinoma of no special type is not merely a passive reaction, but seems to be an integral part of the neoplastic process by facilitating tumor progression and invasion. Additional, larger studies on mechanisms of stromal change are needed and may potentially lead to novel treatments.
SCOPUS: ar.j
info:eu-repo/semantics/published
Databáze: OpenAIRE
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