Quantification of stromal reaction in breast carcinoma and its correlation with tumor grade and free progression survival
Autor: | Michel Jondet, Philippe Simon, Jean Christophe Noël, Michel Vanhaeverbeek, Xavier Catteau |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Psychologie appliquée Cancer Treatment 0302 clinical medicine Animal Cells Breast Tumors Tumor Microenvironment Medicine and Health Sciences Myofibroblasts Connective Tissue Cells Aged 80 and over Multidisciplinary Invasive Tumors Carcinoma Ductal Breast Sciences bio-médicales et agricoles Middle Aged Gene Expression Regulation Neoplastic Oncology Invasive carcinoma of no special type Connective Tissue 030220 oncology & carcinogenesis Disease Progression Medicine Female Anatomy Cellular Types Breast carcinoma Biologie Research Article Adult Stromal cell Histology Imaging Techniques Science Breast Neoplasms Image Analysis Research and Analysis Methods Carcinomas Lymphatic System 03 medical and health sciences Breast cancer medicine Carcinoma Humans Aged Retrospective Studies Tumor microenvironment business.industry Cancer Biology and Life Sciences Cancers and Neoplasms Cell Biology Fibroblasts medicine.disease Survival Analysis Actins 030104 developmental biology Biological Tissue Tumor progression Cancer research Lymph Nodes Neoplasm Grading Stromal Cells business |
Zdroj: | PLoS ONE, Vol 14, Iss 3, p e0210263 (2019) PLoS ONE PloS one, 14 (3 |
ISSN: | 1932-6203 |
Popis: | Cancer progression results from a complex interplay between tumor cells and the extracellular milieu. In breast carcinoma, the stromal microenvironment has been suggested to play a major role in promoting tumor growth, progression, and invasion. The stroma of 154 resected specimens of invasive breast carcinoma of no special type was quantified using a digital image analyzer. Statistical analyses were performed between the quantity of stroma and survival, as well as between progression-free survival and clinicopathological data. Levels of myofibroblastic stroma varied from 0–46%, with a median of 15.1% and a standard deviation of 7.5. The myofibroblastic stromal reaction was statistically greater in grade 2 and 3 tumors (p = 0.029). Furthermore, there was a trend for worse progression-free survival in the group of node-negative tumors with strong smooth-muscle actin stromal expression (Log rank = 0.075). The present study demonstrates that the myofibroblastic reaction of breast invasive carcinoma of no special type is not merely a passive reaction, but seems to be an integral part of the neoplastic process by facilitating tumor progression and invasion. Additional, larger studies on mechanisms of stromal change are needed and may potentially lead to novel treatments. SCOPUS: ar.j info:eu-repo/semantics/published |
Databáze: | OpenAIRE |
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