Chemo-endocrine therapy in patients with stage D2 prostate cancer

Autor: Hidetoshi Yamanaka, Hideki Sakai, Teruhiro Nakada, Yutaka Saito, Isoji Sasagawa, Yoko Kubota, Kyoichi Imai, Osamu Sugano, Koichi Kitamura, Yukio Tomaru
Rok vydání: 1995
Předmět:
Zdroj: The Prostate. 26:50-54
ISSN: 1097-0045
0270-4137
Popis: There have only been a few studies of chemo-endocrine therapy compared with endocrine therapy alone in newly diagnosed prostate cancer patients. We assessed the effects of these two therapies by comparing long-term survival rates. One hundred and twenty-nine patients were entered in this study between November 1977 and March 1992. Seventy-seven patients were treated with endocrine therapy alone. Other 52 patients received chemo-endocrine therapy, which included orchiectomy and/or diethylstilbestrol diphosphate (DES-DP) plus Cisplatin, with or without other cytotoxic agents. All patients had bone metastasis at the beginning of the study. There was a significant difference in survival between patients who received endocrine therapy and chemo-endocrine therapy (P = 0.0078). That is, survival rate was superior for the chemoendocrine therapy patients throughout the entire follow-up period. These data suggest that early chemo-endocrine therapy containing Cisplatin, with or without maintenance chemotherapy, is a potentially effective treatment for newly diagnosed metastatic prostate cancer and is worth further investigation via a randomized trial.
Databáze: OpenAIRE
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