Hemocompatibility, cytotoxicity, and genotoxicity of poly(methylmethacrylate)/nanohydroxyapatite nanocomposites synthesized by melt blending method
| Autor: | Serap Doğan, Serap Celikler Kasimogullari, Begümhan Yılmaz |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Materials science Polymers and Plastics General Chemical Engineering macromolecular substances 02 engineering and technology medicine.disease_cause Analytical Chemistry 03 medical and health sciences chemistry.chemical_compound Poly methylmethacrylate Polymer chemistry medicine Methyl methacrylate Cytotoxicity Nanocomposite technology industry and agriculture equipment and supplies 021001 nanoscience & nanotechnology Melt blending body regions 030104 developmental biology Chemical engineering chemistry 0210 nano-technology Genotoxicity |
| Zdroj: | International Journal of Polymeric Materials and Polymeric Biomaterials. 67:351-360 |
| ISSN: | 1563-535X 0091-4037 |
| Popis: | The aim of this study was to show the hemocompatibility, cytotoxicity, and genotoxicity of nanocomposites that were synthesized with different molecular weights of poly(methyl methacrylate) (PMMA) and different concentrations of nanohydroxyapatite (nHAp). Different techniques to characterize the nanocomposites were used. The cytotoxicity and genotoxic effects of the polymers and nanocomposites on human lymphocytes were determined by acid phosphatase assay, viability test, and comet assay. Moreover, hemocompatibility test was performed. It was found that all of the PMMA/nHAp nanocomposites are highly hemocompatible and biocompatible, none of the nanocomposites showed a cytotoxic effect, and nHAp addition decreased the genotoxicity. |
| Databáze: | OpenAIRE |
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