Clinical efficacy of Curcuvet and Boswellic acid combined with conventional nutraceutical product: An aid to canine osteoarthritis
| Autor: | Federica Aragosa, Alfonso Piscitelli, Francesco Lamagna, Chiara Caterino, Annalisa Nieddu, Dario Costanza, Giovanni Della Valle, Gerardo Fatone |
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| Přispěvatelé: | Caterino, Chiara, Aragosa, Federica, Della Valle, Giovanni, Costanza, Dario, Lamagna, Francesco, Piscitelli, Alfonso, Nieddu, Annalisa, Fatone, Gerardo |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Physiology NSAIDs Osteoarthritis Ascorbic Acid chemistry.chemical_compound Skeletal Joints Glucosamine Medicine and Health Sciences Elbow Vitamin E Boswellia Musculoskeletal System Mammals Analgesics Multidisciplinary biology Chondroitin Sulfates Eukaryota Drugs Arms Neuropathic pain Vertebrates Medicine Boswellic acid Female Anatomy Gait Analysis Research Article medicine.medical_specialty Science Pain Nutraceutical Dogs Signs and Symptoms Rheumatology Internal medicine Fatty Acids Omega-6 medicine Animals Chondroitin sulfate Skeleton Pharmacology Vitamin C business.industry Biological Locomotion Plant Extracts Arthritis Body Weight Organisms Biology and Life Sciences biology.organism_classification medicine.disease Pain management Triterpenes chemistry Body Limbs Amniotes Clinical Medicine business Zoology |
| Zdroj: | PLoS ONE, Vol 16, Iss 5, p e0252279 (2021) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Introduction Osteoarthritis is a progressive degenerative joint disease which is high prevalent in dogs. In the late stage of the disease, it determines chronic neuropathic pain which leads to reduced quality-of-life in affected patients. To date it has not yet been identified a specific treatment, but it has been proved that nutraceutical and dietary supplements may play an important role in controlling inflammation and pain. The aim of this study was to evaluate, by the use of force plate gait analysis, the clinical efficacy of Boswellia and Curcuvet® combined with conventional nutraceutical therapy compared with conventional nutraceutical alone in dogs affected by osteoarthritis. Materials and methods Twenty client-owned dogs, over 12 months old and 20 kg of body-weight, with a confirmed diagnosis of Osteoarthritis, were included in this randomized, double-blinded study. The dogs were randomly divided into two groups: the first group (A) received a conventional nutraceutical (consisted in a preparation of glucosamine, chondroitin sulfate, fish-oil containing 80% of omega 3-fatty acid, vitamin C and E, saccharomyces Cerevisiae) with a combination of acid boswellic and Curcuvet®, while the second group (B) received a conventional nutraceutical. All the enrolled dogs underwent a washout period before starting the treatment with nutraceuticals products which were the only admitted treatment over the study period. A full orthopaedic and neurologic examination, and force plate gait analysis were performed before starting the treatment, at 45, 90, and 60 days post-treatment. Ground reaction forces were recorded and analyzed. Results Twenty dogs were enrolled in the study. In both groups there was an increasing values of ground reaction forces. These results might indicate that both nutraceutical products determined a better condition in terms of pain feeling but that effect is much more visible after 60 days from the end of the administration in treated group. Discussion In conclusion Curcuvet in combination with Boswellic acid could be considered a valid aid in a multimodal treatment for canine osteoarthritis. |
| Databáze: | OpenAIRE |
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