Epiglottis cross-sectional area and oropharyngeal airway length in male and female obstructive sleep apnea patients
| Autor: | Frisca L. Yan-Go, Ronald M. Harper, Melinda A Ma, Rajesh Kumar, Paul M. Macey |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Epiglottis apnea–hypopnea index Clinical Trials and Supportive Activities Clinical Sciences 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Clinical Research Internal medicine Oropharyngeal airway Nature and Science of Sleep gender Medicine Psychology magnetic resonance imaging Lung race Applied Psychology Original Research 2. Zero hunger Sleep disorder business.industry Neurosciences Sleep apnea apnea-hypopnea index medicine.disease 3. Good health respiratory tract diseases Obstructive sleep apnea medicine.anatomical_structure Apnea–hypopnea index 030220 oncology & carcinogenesis Anesthesia Cardiology Respiratory business Airway Sleep Research Body mass index upper-airway length 030217 neurology & neurosurgery |
| Zdroj: | Nature and Science of Sleep |
| ISSN: | 1179-1608 |
| Popis: | Melinda A Ma,1 Rajesh Kumar,2–4 Paul M Macey,4,5 Frisca L Yan-Go,6 Ronald M Harper,1,41Department of Neurobiology, 2Department of Anesthesiology, 3Department of Radiological Sciences, David Geffen School of Medicine, 4Brain Research Institute, 5UCLA School of Nursing, 6Department of Neurology, David Geffen School ofMedicine, University of California at Los Angeles, Los Angeles, CA, USAIntroduction: Obstructive sleep apnea (OSA) is a male-predominant condition, characterized by repeated upper-airway collapse with continued diaphragmatic efforts during sleep, and is accompanied by severe physiological consequences. Multiple morphological aspects, including epiglottis cross-sectional area (CSA) and oropharyngeal airway length (OPAL), can contribute to airway collapsibility in the condition. This study focused on the effects of OSA severity, sex, and race on OPA dimensions.Materials and methods: Two high-resolution T1-weighted image series were collected from 40 mild-to-severe OSA subjects (age 46.9±9 years, body mass index 30.4±5.4 kg/m2, Apnea–Hypopnea Index score 32.8±22.5, 28 males) and 54 control subjects (47±9 years, 24.7±3.8 kg/m2, 32 males) using a 3 T magnetic resonance-imaging scanner. Caucasian, Asian, African-American, and “other” subjects constituted the study pool. Both image series were realigned and averaged, and reoriented to a common space. CSA and OPAL were measured, normalized for subject height, and compared between sexes and disease-severity levels in OSA and control subjects.Results: Significantly reduced epiglottis CSA appeared only in severe OSA vs controls (P=0.009). OPAL increased significantly with OSA severity vs controls (mild, P=0.027; moderate, P |
| Databáze: | OpenAIRE |
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