UV Light from 290 to 325 nm, but not Broad-Band UVA or Visible Light, Augments the Formation of Melanocytic Nevi in a Guinea-Pig Model for Human Nevi
| Autor: | Kerry A. Crotty, Michael E. O'Neill, Gavin E. Greenoak, Chandrika M. Abeywardana, Scott W. Menzies |
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| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Light Ultraviolet Rays 9 10-Dimethyl-1 2-benzanthracene Guinea Pigs DMBA Dermatology Biochemistry Guinea pig medicine melanoma Animals Irradiation skin and connective tissue diseases neoplasms Molecular Biology visible light Skin Nevus Pigmented integumentary system Solar spectra Chemistry Melanoma Broad band Cell Biology Melanocytic nevus medicine.disease Molecular biology Disease Models Animal UVA nevi Carcinogens Female UVB Visible spectrum |
| Zdroj: | Journal of Investigative Dermatology. 123(2):354-360 |
| ISSN: | 0022-202X |
| DOI: | 10.1111/j.0022-202x.2004.23206.x |
| Popis: | We have previously described a guinea-pig model where pigmented nevi similar to human nevi can be produced by application of low-dose topical 7,12-dimethylbenzanthracene (DMBA) followed by solar-simulated light. Five groups of guinea-pigs were used to test the effect of various spectral bands of solar-simulated light on low-dose DMBA-induced melanocytic nevi. Animals were irradiated with either UVB to near UVA2 (290–325 nm), UVA, visible light, full solar spectrum or no irradiation three times per wk for 12 mo to determine the broad-band effect of nevi-inducing irradiation. There was a significant increase in nevi/animal in the UVB-treated group (mean 1.53) compared with all groups (versus UVA 0.3, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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