Association of Circulating Follistatin-Like 1 Levels with Inflammatory and Oxidative Stress Markers in Healthy Men

Autor: Toyoaki Murohara, Rei Shibata, Koji Ohashi, Nobuo Ikeda, Masanori Ito, Hayato Ogawa, Ryotaro Takahashi, Naoya Otaka, Noriyoshi Kanemura, Satoko Hayakawa, Noriyuki Ouchi, Mizuho Hiramatsu-Ito
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Physiology
medicine.medical_treatment
lcsh:Medicine
Disease
030204 cardiovascular system & hematology
Cardiovascular Medicine
medicine.disease_cause
Pathology and Laboratory Medicine
Biochemistry
chemistry.chemical_compound
0302 clinical medicine
Mathematical and Statistical Techniques
Medicine and Health Sciences
Diabetes diagnosis and management
Insulin
lcsh:Science
Immune Response
Multidisciplinary
biology
Fasting
Hematology
Middle Aged
Lipids
Body Fluids
C-Reactive Protein
Blood
Cholesterol
Cardiovascular Diseases
Physical Sciences
Regression Analysis
medicine.symptom
Anatomy
Statistics (Mathematics)
Research Article
medicine.medical_specialty
Follistatin-Related Proteins
HbA1c
Inflammatory Diseases
Immunology
Inflammation
Research and Analysis Methods
Blood Plasma
03 medical and health sciences
Signs and Symptoms
Asian People
Internal medicine
medicine
Humans
Hemoglobin
Statistical Methods
C-reactive protein
lcsh:R
Biology and Life Sciences
Proteins
Cell Biology
medicine.disease
Diagnostic medicine
Oxidative Stress
030104 developmental biology
Endocrinology
chemistry
biology.protein
lcsh:Q
Oxidative stress
Biomarkers
Mathematics
Kidney disease
Follistatin
Zdroj: PLoS ONE, Vol 11, Iss 5, p e0153619 (2016)
PLoS ONE
ISSN: 1932-6203
Popis: Objectives Follistatin-like 1 (Fstl1) is a circulating glycoprotein that plays a crucial role in cardiovascular diseases and inflammation-related disorders. We have shown that Fstl1 acts as an anti-inflammatory factor that protects against ischemic heart disease and chronic kidney disease. Here we examined whether plasma level of Fstl1 associates with markers of inflammation and oxidative stress in apparently healthy Japanese men. Methods and Results Plasma Fstl1 levels were measured by enzyme-linked immunosorbent assay. Circulating Fstl1 concentrations positively correlated with levels of fasting immune-reactive insulin (FIRI), high-sensitive CRP (hsCRP) and derivatives of reactive oxidative metabolites (dROMs), an indicator of oxidative stress. The levels of hsCRP positively associated with Fstl1, body mass index (BMI), triglyceride, FIRI and dROMs levels. dROMs levels positively associated with Fstl1, Hemoglobin A1c and hsCRP levels. Multiple regression analysis with confounding factors revealed that Fstl1 levels, together with BMI and FIRI, correlated with hsCRP and that Fstl1 levels correlated with dROMs. Conclusion Our observations indicate that measurement of plasma Fstl1 levels can be valuable for assessment of pro-inflammatory and oxidative stress conditions.
Databáze: OpenAIRE
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