| Autor: |
Chia-Che Chen, Ray-Jade Chen, Yu-Min Huang, Po-Li Wei, Yan-Juin Huang, Wei-Chih Chen, Yiu-Shun Tong, Li Jen Kuo |
| Rok vydání: |
2020 |
| Předmět: |
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| Popis: |
Background: Studies reporting the results of associated factors of pathological completed response (PCR) and tumor regression response in patients with rectal cancer following neoadjuvant chemoradiation therapy (nCRT) are inconsistent. Objective: The purpose of this study was to identify the prognostic factors of tumor response and outcome in rectal cancer patients. Design: The study was a retrospective analysis. Settings: The study was conducted in a single large institution in Taiwan. Patients: Newly diagnosed rectal cancer patients who underwent nCRT followed by surgery from 2010 to 2014 with 5 years of follow-up. Main Outcome Measures: The primary outcomes were associated factors of pathological completed response and downstaging. The risk factors of survival outcome and disease recurrence were also observed. Results: A total of 169 rectal cancer patients were included. The PCR rate was 17.8%, and the downstaging rate was 60.9%. Patients with a histology type of adenocarcinoma associated with PCR, and patients positive for clinical N stage were associated with downstaging. Kaplan-Meier analysis showed the PCR group performed better to a statistically significant level both in overall survival and disease recurrence free survival than the no PCR group (p= 0.033 & 0.025, respectively). Patients with a downstaging response also showed better overall survival benefits and disease recurrence free survival benefits than their counterparts (both p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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