Inhibin is an important factor in the regulation of FSH secretion in the adult male hamster
| Autor: | Mariko Itoh, Wanzhu Jin, Kazuyoshi Taya, Natsuko Nagamine, Sachiko Wada, Gen Watanabe, Hisashi Kishi, Yumiko Tanaka, Yoko Yukinari |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
endocrine system medicine.medical_specialty 3-Hydroxysteroid Dehydrogenases Time Factors Antineoplastic Agents Hormonal Physiology medicine.drug_class Endocrinology Diabetes and Metabolism Hamster Andrology chemistry.chemical_compound Follicle-stimulating hormone Cricetinae Physiology (medical) Internal medicine Testis medicine Animals Inhibins Testosterone Sertoli Cells Mesocricetus biology Leydig Cells Luteinizing Hormone biology.organism_classification Androgen Immunohistochemistry Flutamide Gonadotropin secretion Castration Endocrinology chemistry Follicle Stimulating Hormone Gonadotropin Orchiectomy hormones hormone substitutes and hormone antagonists |
| Zdroj: | American Journal of Physiology-Endocrinology and Metabolism. 278:E744-E751 |
| ISSN: | 1522-1555 0193-1849 |
| DOI: | 10.1152/ajpendo.2000.278.4.e744 |
| Popis: | We investigated the importance of inhibin and testosterone in the regulation of gonadotropin secretion in adult male golden hamsters ( Mesocricetus auratus). After castration, plasma concentrations of inhibin and testosterone were reduced to undetectable, whereas plasma follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were increased. After hemicastration, plasma FSH and LH increased moderately and plasma inhibin decreased to one-half its initial level. Plasma testosterone levels in hemicastrated animals decreased 3 h after hemicastration but returned to those in sham-operated animals at 6 h. Plasma LH in the castrated hamster declined comparably to intact animals with testosterone treatment; plasma FSH also decreased but still remained at levels higher than those in intact animals. After treatment with inhibin in long-term-castrated animals, plasma FSH decreased, whereas plasma LH was not altered. Intact males treated with flutamide, an anti-androgen, showed a significant increase in plasma LH but not in FSH. On the other hand, treatment with anti-inhibin serum induced a significant elevation in plasma FSH, but not in LH. Using immunohistochemistry, we showed that the inhibin α-subunit was localized to both Sertoli and Leydig cells. The present study in adult male hamsters indicates that FSH secretion is regulated mainly by inhibin, presumably from Sertoli and Leydig cells, and that LH secretion is controlled primarily by androgens produced from the Leydig cells. This situation is more similar to that of primates than of rats. |
| Databáze: | OpenAIRE |
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