Beta-Blockers and Berberine: A Possible Dual Approach to Contrast Neuroblastoma Growth and Progression
| Autor: | Angela Subbiani, Claudio Favre, Gennaro Bruno, Maura Calvani |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Aging
Berberine Adrenergic beta-Antagonists Review Article Biochemistry Neuroblastoma chemistry.chemical_compound medicine Animals Humans Cell Proliferation QH573-671 biology Brain Neoplasms business.industry Alkaloid Therapeutic effect Cancer Cell Biology General Medicine medicine.disease chemistry Tumor progression Apoptosis Dietary Supplements Disease Progression biology.protein Cancer research Monoamine oxidase A Cytology business |
| Zdroj: | Oxidative Medicine and Cellular Longevity, Vol 2020 (2020) Oxidative Medicine and Cellular Longevity |
| ISSN: | 1942-0994 1942-0900 |
| DOI: | 10.1155/2020/7534693 |
| Popis: | The use of nutraceuticals during cancer treatment is a long-lasting debate. Berberine (BBR) is an isoquinoline quaternary alkaloid extracted from a variety of medicinal plants. BBR has been shown to have therapeutic effects in different pathologies, particularly in cancer, where it affects pathways involved in tumor progression. In neuroblastoma, the most common extracranial childhood solid tumor, BBR, reduces tumor growth by regulating both stemness and differentiation features and by inducing apoptosis. At the same time, the inhibition of β-adrenergic signaling leads to a reduction in growth and increase of differentiation of neuroblastoma. In this review, we summarize the possible beneficial effects of BBR in counteracting tumor growth and progression in various types of cancer and, in particular, in neuroblastoma. However, BBR administration, besides its numerous beneficial effects, presents a few side effects due to inhibition of MAO A enzyme in neuroblastoma cells. Therefore, herein, we proposed a novel therapeutic strategy to overcome side effects of BBR administration consisting of concomitant administration of BBR together with β-blockers in neuroblastoma. |
| Databáze: | OpenAIRE |
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