LoC sensor array platform for real-time coagulation measurements
| Autor: | Erhan Ermek, Göksenin Yaralıoğlu, Aref Mostafazadeh, Caglar Elbuken, Necmettin Kılınç, Onur Cakmak, Hakan Urey |
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| Přispěvatelé: | Özyeğin University, Yaralıoğlu, Göksenin |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Electrical connection
Materials science Coagulation time Projectiles Microsensors Prothrombin time Microfluidics law.invention Composite micromechanics Cartridge Sensor array law Electronic engineering Coagulation (water treatment) Disposable cartridge Electric connectors Platform technology Microelectromechanical systems Coagulation Microprocessor chips Lab-on-a-chip Sensors Micro-cantilevers business.industry Laser Coagulation tests MEMS Optoelectronics MEMS-based sensors business Microfluidic channel |
| Zdroj: | International Conference on Micro Electro Mechanical Systems |
| Popis: | Due to copyright restrictions, the access to the full text of this article is only available via subscription. This paper reports a MEMS-based sensor array enabling multiple clot-time tests in one disposable microfluidic cartridge using plasma. The versatile LoC (Lab-on-Chip) platform technology is demonstrated here for real-time coagulation tests (activated Partial Thrompoblastin Time (aPTT) and Prothrombin Time (PT)). The system has a reader unit and a disposable cartridge. The reader has no electrical connections to the cartridge, which consists of multiple microfluidic channels and MEMS microcantilevers placed in each channel. Microcantilevers are made of electro-plated nickel and actuated remotely using an external electro-coil. The read-out is also conducted remotely by a laser and the phase of the MEMS oscillator is monitored real-time. The system is capable of monitoring coagulation time with a precision estimated at 0.1sec. TÜBİTAK |
| Databáze: | OpenAIRE |
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