A self‐adhesive microneedle patch with drug loading capability through swelling effect
| Autor: | Chenjie Xu, Christian Wiraja, Sharon Wan Ting Chew, Terry W. J. Steele, Ankur Harish Shah, Mengjia Zheng, Hao Chang |
|---|---|
| Přispěvatelé: | School of Chemical and Biomedical Engineering, School of Materials Science and Engineering |
| Rok vydání: | 2020 |
| Předmět: |
Research Report
Drug microneedles Materials science lcsh:Biotechnology media_common.quotation_subject Bioadhesive Biomedical Engineering bioadhesive Pharmaceutical Science dendrimer chemistry.chemical_compound self‐adhesive lcsh:TP248.13-248.65 Dendrimer Hyaluronic acid Stratum corneum medicine lcsh:Chemical engineering Transdermal media_common Materials [Engineering] lcsh:RM1-950 technology industry and agriculture lcsh:TP155-156 Research Reports Penetration (firestop) transdermal drug delivery lcsh:Therapeutics. Pharmacology medicine.anatomical_structure chemistry Swelling medicine.symptom Biotechnology Biomedical engineering |
| Zdroj: | Bioengineering & Translational Medicine Bioengineering & Translational Medicine, Vol 5, Iss 2, Pp n/a-n/a (2020) |
| ISSN: | 2380-6761 |
| DOI: | 10.1002/btm2.10157 |
| Popis: | Microneedles (MNs) offer a rapid method of transdermal drug delivery through penetration of the stratum corneum. However, commercial translation has been limited by fabrication techniques unique to each drug. Herein, a broadly applicable platform is explored by drug-loading via swelling effect of a hydrogel MN patch. A range of small molecule hydrophilic, hydrophobic, and biomacromolecule therapeutics demonstrate successful loading and burst release from hydrogel MNs fabricated from methacrylated hyaluronic acid (MeHA). The post-fabrication drug loading process allows MeHA MN patches with drug loadings of 10 μg cm-2. Additional post-fabrication processes are explored with dendrimer bioadhesives that increase work of adhesion, ensuring stable fixation on skin, and allow for additional drug loading strategies. Agency for Science, Technology and Research (A*STAR) Ministry of Education (MOE) Published version This work was supported by Singapore MOE Academic Research Fund (AcRF) Tier 1 grant (RG49/18), Additive Manufacturing for Biological Materials (AMBM) Program (A18A8b0059 to XCJ) from Singapore A*STAR Science and Engineering Research Council (SERC). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|