Automatic identification of atypical clinical fMRI results
| Autor: | Nick F. Ramsey, Gord von Campe, J. Martijn Jansma, Lenny Ramsey, Tom J. Snijders, Mar Jiménez de la Peña, Margit Jehna, Geert-Jan Rutten, Katharina Rosengarth, Alberto Bizzi, Elke Hattingen, Frank Dodoo-Schittko |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Neurology Adolescent Neuroimaging Brain function Proof of Concept Study 030218 nuclear medicine & medical imaging Limited access 03 medical and health sciences 0302 clinical medicine Task Performance and Analysis Image Processing Computer-Assisted Medicine Humans Radiology Nuclear Medicine and imaging Neuroradiology Functional MRI Language business.industry Brain Neoplasms Healthy subjects Correction Functional Neuroradiology Glioma Middle Aged Magnetic Resonance Imaging Healthy Volunteers Europe Identification (information) Data quality Clinical fMRI Finger tapping Motor cortex Feasibility Studies Female Neurology (clinical) Radiology Objective evaluation Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery |
| Zdroj: | Neuroradiology |
| ISSN: | 1432-1920 |
| Popis: | Purpose Functional MRI is not routinely used for neurosurgical planning despite potential important advantages, due to difficulty of determining quality. We introduce a novel method for objective evaluation of fMRI scan quality, based on activation maps. A template matching analysis (TMA) is presented and tested on data from two clinical fMRI protocols, performed by healthy controls in seven clinical centers. Preliminary clinical utility is tested with data from low-grade glioma patients. Methods Data were collected from 42 healthy subjects from seven centers, with standardized finger tapping (FT) and verb generation (VG) tasks. Copies of these “typical” data were deliberately analyzed incorrectly to assess feasibility of identifying them as “atypical.” Analyses of the VG task administered to 32 tumor patients assessed sensitivity of the TMA method to anatomical abnormalities. Results TMA identified all atypical activity maps for both tasks, at the cost of incorrectly classifying 3.6 (VG)–6.5% (FT) of typical maps as atypical. For patients, the average TMA was significantly higher than atypical healthy scans, despite localized anatomical abnormalities caused by a tumor. Conclusion This study supports feasibility of TMA for objective identification of atypical activation patterns for motor and verb generation fMRI protocols. TMA can facilitate the use and evaluation of clinical fMRI in hospital settings that have limited access to fMRI experts. In a clinical setting, this method could be applied to automatically flag fMRI scans showing atypical activation patterns for further investigation to determine whether atypicality is caused by poor scan data quality or abnormal functional topography. |
| Databáze: | OpenAIRE |
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