Hormonal and metabolic profiles of obese and nonobese type 2 diabetes patients: implications of plasma insulin, ghrelin, and vitamin D levels

Autor: Hayder A, Giha, Dhuha M B, AlDehaini, Faris E, Joatar, Muhalab E, Ali, Einas M, Al-Harbi, Ali A, Al Qarni
Rok vydání: 2022
Předmět:
Zdroj: Cardiovascular Endocrinology & Metabolism
ISSN: 2574-0954
DOI: 10.1097/xce.0000000000000256
Popis: Background Type 2 diabetes (T2D) is associated with obesity whereas loss of weight is a feature of the disease; however, the two states are not mutually exclusive. Obesity is linked with changes in hormonal activity and overall body metabolism. Materials and methods In this study, 408 T2D patients were recruited in three distinct studies conducted in Bahrain, Saudi Arabia, and Kuwait in three different intervals between 2001 and 2019. In addition to demographics, glycemic and lipid profiles were obtained in all studies, whereas plasma insulin and HOMA-IR, vitamin D, and ghrelin were analyzed in Saudi Arabia. Different techniques such as chemical auto-analyzer, ELISA, chemiluminescent immunoassay, radioimmunoassay were used. Results The obese (BMI ≥ 30 kg/m2) compared with nonobese (BMI 18.5 to
Databáze: OpenAIRE