SAP controls T cell responses to virus and terminal differentiation of TH2 cells
| Autor: | Khuong B. Nguyen, Persephone Borrow, Arlene H. Sharpe, Christine A. Biron, Miriam Rodriguez Sosa, Ninghai Wang, Chengbin Wu, Matthew J. Edwards, Duncan Howie, Charles A. Gullo PhD, Cox Terhorst, Abhay R. Satoskar, Gary C. Pien |
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| Rok vydání: | 2001 |
| Předmět: |
CD4-Positive T-Lymphocytes
genetic structures T-Lymphocytes Cellular differentiation T cell Immunology Leishmaniasis Cutaneous CD8-Positive T-Lymphocytes Lymphocytic Choriomeningitis Biology Lymphocytic choriomeningitis Virus Interferon-gamma Mice Th2 Cells Immune system Signaling lymphocytic activation molecule medicine Animals Immunology and Allergy Cytotoxic T cell Signaling Lymphocytic Activation Molecule Associated Protein Intracellular Signaling Peptides and Proteins Cell Differentiation Immunoglobulin E medicine.disease Lymphoproliferative Disorders Mice Mutant Strains medicine.anatomical_structure Liver Cytokines Carrier Proteins Spleen CD8 Signal Transduction |
| Zdroj: | Nature Immunology. 2:410-414 |
| ISSN: | 1529-2916 1529-2908 |
| DOI: | 10.1038/87713 |
| Popis: | SH2D1A, which encodes signaling lymphocyte activation molecule (SLAM)-associated protein (SAP), is altered in patients with X-linked lymphoproliferative disease (XLP), a primary immunodeficiency. SAP-deficient mice infected with lymphocytic choriomeningitis virus had greatly increased numbers of CD8+ and CD4+ interferon-gamma-producing spleen and liver cells compared to wild-type mice. The immune responses of SAP-deficient mice to infection with Leishmania major together with in vitro studies showed that activated SAP-deficient T cells had an impaired ability to differentiate into T helper 2 cells. The aberrant immune responses in SAP-deficient mice show that SAP controls several distinct key T cell signal transduction pathways, which explains in part the complexity of the XLP phenotypes. |
| Databáze: | OpenAIRE |
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