Fatal interstitial pneumonia in juvenile dermatomyositis
| Autor: | Takahisa Mizuno, Yayoi Nagai, Chikage Yoshizawa, Osamu Ishikawa |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Pathology Cyclophosphamide Dermatology Methylprednisolone Gastroenterology Dermatomyositis Fatal Outcome Fructose-Bisphosphate Aldolase Internal medicine medicine Humans Muscle Skeletal Glucocorticoids Juvenile dermatomyositis biology business.industry Gluteus minimus Respiratory disease Immunoglobulins Intravenous biology.organism_classification medicine.disease Magnetic Resonance Imaging Connective tissue disease Rash Pulse Therapy Drug Child Preschool Cyclosporine biology.protein Female Creatine kinase medicine.symptom Lung Diseases Interstitial business Immunosuppressive Agents medicine.drug |
| Zdroj: | European Journal of Dermatology. 20:208-210 |
| ISSN: | 1952-4013 1167-1122 |
| DOI: | 10.1684/ejd.2010.0846 |
| Popis: | A 5-year-old girl presented with a two-month-history of skin rash and general fatigue. She had a slight fever, progressive muscle weakness and liver dysfunction. Gottron's papules on her fingers and purple-reddish papules on her elbows were noted. Serum aldolase levels were highly elevated, however, creatine phosphokinase levels were normal. An MRI revealed abnormal high signal changes in her gluteus minimus muscles. Interstitial pneumonia suddenly developed and she died despite aggressive treatment with methylprednisolone pulse therapy followed by intravenous administration of cyclophosphamide, immunoglobulin and cyclosporine A. Interstitial pneumonia is rare in juvenile dermatomyositis; however, as in adult cases, it can be fatal. In order to prevent severe complications and functional disabilities, early aggressive treatments should be considered when muscle inflammation is refractory to ordinary treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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