Pharmacokinetic of a very low molecular weight heparin in chronic renal failure
Autor: | B. Bayrou, B. Hory, M.H. Claudet, J. Magnette, P. Bechtel |
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Rok vydání: | 1991 |
Předmět: |
medicine.medical_specialty
Metabolic Clearance Rate medicine.drug_class Urology Low molecular weight heparin Renal function Pharmacokinetics Renal Dialysis medicine Humans Statistical analysis Stage (cooking) business.industry Anticoagulant Thrombosis Hematology Heparin Heparin Low-Molecular-Weight Middle Aged Surgery Creatinine Drug Evaluation Kidney Failure Chronic Chronic renal failure business Factor Xa Inhibitors medicine.drug |
Zdroj: | Thrombosis Research. 63:311-317 |
ISSN: | 0049-3848 |
DOI: | 10.1016/0049-3848(91)90134-i |
Popis: | The pharmacokinetic characteristics of a low molecular weight heparin (LMWH) (Cy 222; mean mw: 2500 daltons) are studied in 24 patients with 3 degrees of chronic renal failure (CRF) stage I (creatinine clearance between 50 and 30 ml/mn), stage 2 (creatine clearance between 30 and 10 ml/mn), stage 3 (creatinine clearance below 10 ml/mn). Patients with CRF have significantly higher values of anti Xa activity at 3 hours (p less than 0.05), 5 hours (p less than 0.05), and at 8 hours (p less than 0.03) after injection than controls, CMAX values, VDSS and AUC do not differ, whereas patients with the highest stage of CRF are characterised by the most important t1/2 a (p less than 0.001) and the smallest total body clearance (p less than 0.01). Consequences of these disturbances of pharmacokinetic characteristics have to be evaluated before adequate posology of heparin fragments could be determined in patients with CRF. |
Databáze: | OpenAIRE |
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