Human amniotic membrane for the treatment of large and refractory macular holes: a retrospective, multicentric, interventional study
| Autor: | Luiz Felipe Hagemann, Pedro Hélio Estevam Ribeiro Júnior, Flavio A. Rezende, Raquel Eustaquio Alves Ferreira, André Maia, André Jucá Machado, Magno Antônio Ferreira |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty genetic structures Large macular-hole Controlled studies 03 medical and health sciences 0302 clinical medicine Refractory Macular-hole reoperations Ophthalmology Chart review Medicine Macular-hole Macular hole Snellen chart Symptoms duration business.industry Human amniotic membrane Internal limiting membrane RE1-994 medicine.disease Macular surgery eye diseases 030104 developmental biology Concomitant 030221 ophthalmology & optometry Original Article business |
| Zdroj: | International Journal of Retina and Vitreous, Vol 7, Iss 1, Pp 1-8 (2021) International Journal of Retina and Vitreous |
| ISSN: | 2056-9920 |
| Popis: | Background The purpose of the current study is to report the anatomical and functional results of off-label human amniotic membrane graft as primary intervention to repair large to giant macular holes and in reoperations when wide internal limiting membrane peeling was unsuccessful. Methods Retrospective chart review was carried out in five different centers to identify all cases that had undergone off-label human amniotic membrane graft for the treatment of large or failed macular holes (MH). Data collected included age, gender, other concomitant diagnosis, symptoms duration, lens status, number of previous surgeries, macular hole measurements (minimum and base linear diameters), mean post-operative follow-up (months), and pre- and post-operative best corrected visual acuity (BCVA). Main outcome measures were anatomical MH closure rates and final BCVA (in logMAR). Nonparametric Wilcoxon rank-sum test was used because the data was not normally distributed, a P values Results Nineteen eyes of 19 patients were identified and included in the study. Mean age was 66.21 ± 14.96 years and predominantly females (84%). All eyes had successfully closed MH with a single intervention with no recurrences during a mean of 9 ± 3.87 months follow-up. The median BCVA in logMAR preoperative was 1.30 ± 0.44 (0.80–2.0), approximately 20/400 on Snellen chart and the median BCVA in logMAR postoperative was 1.0 ± 0.72 (0.4–3.0) approximately 20/200 (p Conclusion The use of human amniotic membrane graft seems to be a viable and effective alternative for the treatment of large and persistent macular holes. However, further larger prospective controlled studies are necessary to confirm our preliminary results of this new surgical technique. |
| Databáze: | OpenAIRE |
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