Use of urinary metabolomics to evaluate the effect of hyperuricemia on the kidney
Autor: | Chia-Chung Hou, Chi Chang Huang, Bih-Show Lou, Feng-Lin Hsu |
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Rok vydání: | 2013 |
Předmět: |
Male
STAT3 Transcription Factor medicine.medical_specialty Urinary system Inflammation Urine Hyperuricemia Biology urologic and male genital diseases Toxicology Kidney Blood Urea Nitrogen chemistry.chemical_compound Metabolomics Internal medicine medicine Animals Interleukin 6 Mice Inbred ICR Interleukin-6 nutritional and metabolic diseases General Medicine Nephrons Acute Kidney Injury medicine.disease Uric Acid Proteinuria Endocrinology medicine.anatomical_structure chemistry Creatinine biology.protein Uric acid medicine.symptom Food Science Signal Transduction |
Zdroj: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 74 |
ISSN: | 1873-6351 |
Popis: | Clinical studies show that hyperuricemia is a risk factor in the progression and development of cardiovascular and metabolic disease. Elevated serum levels of uric acid induce renal injury via an inflammation response, but the detailed mechanism is still under study. To better understand the effect of hyperuricemia on the kidney, we used gas chromatography–mass spectrometry-based metabolomics to investigate the role of uric acid in the mouse kidney. Partial least-squares discriminant analysis revealed significant differences between control and hyperuricemia groups in urine metabolic profiles. We identified 33 metabolites from 76 highly reproducible peaks and found abnormal uric acid levels related to comprehensive kidney injury, including excretive function and energy metabolism. Additionally, inflammation induced by the interleukin 6/signal transducer and activator of transcription 3 signaling pathway participated in hyperuricemia-induced kidney injury. This study helps understand the relationship between hyperuricemia and kidney injury. Metabolomics may be a useful strategy for early diagnosis of kidney damage. |
Databáze: | OpenAIRE |
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