Serum gastrin levels following administration of omeprazole alone or in combination with pirenzepine
| Autor: | Kazuro Ito, Yoshinori Sakai, You Kawamura, Yasuyuki Arakawa, Koji Miyazawa, Ariyoshi Iwasaki, Yoshinori Tashiro, Yutaka Matsuo |
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| Rok vydání: | 1994 |
| Předmět: |
Peptic Ulcer
medicine.medical_specialty business.industry Ulcer recurrence Significant difference Gastroenterology Pirenzepine Hepatology Serum gastrin Duodenal ulcer Endocrinology Duodenal Ulcer Internal medicine Gastrins medicine Humans Drug Therapy Combination In patient Stomach Ulcer business Omeprazole medicine.drug |
| Zdroj: | Journal of Gastroenterology. 29:398-402 |
| ISSN: | 1435-5922 0944-1174 |
| DOI: | 10.1007/bf02361234 |
| Popis: | Serum gastrin levels in 44 peptic ulcer patients (26 gastric ulcer patients and 18 duodenal ulcer patients) were determined after they had been treated with omeprazole (OPZ) (20 mg/day) alone or in combination with pirenzepine (PZP) (100 mg/day). Serum gastrin levels were measured before, as well as 2, 4 and 6 weeks after administration, and the changes were compared. The levels were significantly elevated (twofold) at 2 weeks of treatment in both the OPZ and OPZ plus PZP groups. In patients taking OPZ alone, the levels rose up to 6 weeks, while in those taking OPZ plus PZP the levels decreased at 4 and 6 weeks. At 4 weeks, serum gastrin levels in the OPZ plus PZP group were lower (although not significantly) than those in patients taking OPZ alone. In gastric ulcer patients, serum gastrin levels in the OPZ group were significantly elevated, while in the OPZ plus PZP group, these levels were only slightly, but not significantly elevated. There was no significant difference between the two gastric ulcer groups at any time. In duodenal ulcer patients, serum gastrin levels increased significantly at 2 weeks of treatment in both groups. At 4 weeks and thereafter, the serum gastrin levels remained significantly high in patients taking OPZ alone, while they decreased at both 4 and 6 weeks in patients taking OPZ plus PZP. Thus, serum gastrin levels in duodenal ulcer patients were markedly decreased by the addition of PZP. These results demonstrate that PZP inhibits the increase in serum gastrin levels induced by OPZ, and suggest that PZP may suppress the rebound hyperacidity that occurs after treatment with OPZ, thus preventing ulcer recurrence. |
| Databáze: | OpenAIRE |
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