The Role of Actin in Muscle Spasms in a Case Series of Patients with Advanced Basal Cell Carcinoma Treated with a Hedgehog Pathway Inhibitor
| Autor: | Liang Joo Leow, Natalie Teh |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
animal structures
medicine.medical_treatment Dermatology Muscle spasm Hedgehog pathway inhibitor Sonidegib 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Myocyte Case Series Basal cell carcinoma skin and connective tissue diseases Hedgehog Actin integumentary system business.industry fungi Cancer medicine.disease Hedgehog signaling pathway Radiation therapy chemistry 030220 oncology & carcinogenesis Cancer research medicine.symptom business muscle spasm |
| Zdroj: | Dermatology and Therapy |
| ISSN: | 2190-9172 2193-8210 |
| Popis: | Basal cell carcinoma (BCC) is the most common cancer globally, with the incidence increasing worldwide by approximately 1% annually. While most cases of BCC can be treated surgically, advanced BCC often poses treatment challenges for patients unsuitable for, or refractory to, radiotherapy and surgery. Since the majority of cases of BCC demonstrate Hedgehog signaling hyperactivation, Hedgehog pathway inhibitors provide durable treatment options and improved clinical outcomes for patients with advanced BCC. One of the most common adverse events seen in patients taking Hedgehog inhibitors includes muscle spasms, which are hypothesized to occur because of calcium influx into the muscle cells. Here we present a case series of patients with muscle spasms during treatment with sonidegib and propose an alternate etiology related to increased actin expression. |
| Databáze: | OpenAIRE |
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