Intravenous immune globulin reduces the need for exchange transfusions in Rhesus and AB0 incompatibility
| Autor: | Jo Røislien, K. M. N. Huizing, Thor Willy Ruud Hansen |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Quality Control
Pediatrics medicine.medical_specialty Time Factors medicine.medical_treatment Exchange Transfusion Whole Blood Exchange transfusion Immunoglobulin E Rh Isoimmunization Medical Records ABO Blood-Group System Intensive Care Units Neonatal Confidence Intervals Odds Ratio Medicine Humans Whole blood Retrospective Studies biology business.industry Norway Immunoglobulins Intravenous Retrospective cohort study Bilirubin General Medicine Odds ratio Phototherapy Blood Group Incompatibility Pediatrics Perinatology and Child Health Cohort biology.protein Antibody business Rh blood group system |
| Zdroj: | Acta paediatrica (Oslo, Norway : 1992). 97(10) |
| ISSN: | 0803-5253 |
| Popis: | Aim: To conduct a quality control review of a single institution experience with intravenous immune globulin in the treatment of Rhesus and AB0 incompatibility. Methods: Intravenous immune globulin as treatment for Rhesus and AB0 incompatibility was introduced in our hospital in 1998. We performed a chart review of 176 infants with Rhesus or AB0 incompatibility treated in our hospital between 1993 and 2003, divided into a historical control group (1993–1998) and a treatment group (1999–2003). The project was approved through institutional ethics procedures. Results: The use of exchange transfusion as a therapeutic modality was significantly reduced in the cohort treated with intravenous immune globulin (OR 0.11; 95% CI 0.046–0.26, p < 0.001). We found no difference between the intravenous immune globulin group and the infants receiving only exchange transfusion as far as the duration of phototherapy. Infants with Rhesus incompatibility had a higher need for top-up transfusions than those with AB0 incompatibility. Conclusion: This study supports the evidence from previous studies suggesting that intravenous immune globulin significantly reduces the need for exchange transfusion in infants with Rhesus and AB0 incompatibility. |
| Databáze: | OpenAIRE |
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