Nanomedicine-Cum-Carrier by Co-Assembly of Natural Small Products for Synergistic Enhanced Antitumor with Tissues Protective Actions
| Autor: | Jiacheng Wang, Xin Yang, Ying Han, Wenshu Qiao, Haitian Zhao, Jianjun Cheng |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Materials science
Paclitaxel Cell Survival Surface Properties Multifunctional nanoparticles Molecular Conformation Breast Neoplasms Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Mice Drug Delivery Systems Cell Line Tumor Animals Humans General Materials Science Co assembly Oleanolic Acid Particle Size Cell Proliferation Biological Products Drug Carriers Mice Inbred BALB C Mammary Neoplasms Experimental Stereoisomerism 021001 nanoscience & nanotechnology Antineoplastic Agents Phytogenic 0104 chemical sciences Biological safety Nanomedicine Drug delivery MCF-7 Cells Glycyrrhetinic Acid Nanoparticles Female Drug Screening Assays Antitumor 0210 nano-technology |
| Zdroj: | ACS Applied Materials & Interfaces. 12:42537-42550 |
| ISSN: | 1944-8252 1944-8244 |
| Popis: | The application of natural small products with self-assembly characteristics in a drug-delivery system is attractive for biomedical applications because of its inherent biological safety and pharmacological activity, and there is no complex structural modification process. However, drug carriers with pharmacological effects have not been developed enough. Here, we report a pure natural nanomedicine-cum-carrier (NMC) drug delivery system. The NMC is formed by the direct co-assembly of two small molecular natural compounds through noncovalent interaction, and a molecular dynamics model for predicting the co-assembly of two small molecular compounds was established. The representative co-assembled NMC (oleanolic acid and glycyrrhetinic acid) not only shows excellent stability, high drug loading, and sustained release characteristics but also the co-assembled NMC formed by two small molecular compounds has a synergistic antitumor effect (CI0.7). After drug loading, the antitumor effect is further improved. In addition, this NMC highlights the unique advantages of active natural products in biosafety and health benefits. Compared with free drugs, it can reduce the liver damage caused by chemotherapy drugs through upregulating key antioxidant pathways. Compared to nonpharmacologically active drug delivery systems, it can reduce the risk of nanotoxicity. Taken together, this co-assembly drug-carrier system overcomes the shortcomings that pharmacologically active compounds cannot be directly applied, enhances the pharmacological activity of bioactive drug carriers, improves the antitumor efficacy, and slows down the side effects induced by chemotherapy drugs and the additional toxicity caused by long-term use of non-bioactive nanocarriers. |
| Databáze: | OpenAIRE |
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