Differential Health Effects on Inflammatory, Immunological and Stress Parameters in Professional Soccer Players and Sedentary Individuals after Consuming a Synbiotic. A Triple-Blinded, Randomized, Placebo-Controlled Pilot Study

Autor: Daniel López-Plaza, Eduardo Ortega, Marta Fernández, Pedro Manonelles, María Dolores Hinchado, Oriol Abellán-Aynés, Luis Andreu-Caravaca, Isabel Gálvez, Carmen Daniela Quero
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
0301 basic medicine
Bifidobacterium longum
Corticotropin-Releasing Hormone
Dopamine
medicine.medical_treatment
Interleukin-1beta
Oligosaccharides
Pilot Projects
Synbiotics
law.invention
Probiotic
stress
0302 clinical medicine
law
Surveys and Questionnaires
Accelerometry
Medicine
TX341-641
Nutrition and Dietetics
biology
Lacticaseibacillus rhamnosus
synbiotic
anxiety
Epinephrine
Research Design
prebiotic
Anxiety
Female
medicine.symptom
probiotic
medicine.drug
Adult
medicine.medical_specialty
Adrenocorticotropic hormone
Placebo
Article
Young Adult
03 medical and health sciences
Bifidobacterium animalis
Lactobacillus rhamnosus
Internal medicine
Humans
Students
Exercise
business.industry
Nutrition. Foods and food supply
Probiotics
Prebiotic
030229 sport sciences
biology.organism_classification
Neurosecretory Systems
soccer
immunity
030104 developmental biology
Athletes
inflammation
Immune System
sedentarism
Sedentary Behavior
Sleep
business
Biomarkers
Stress
Psychological
Food Science
Zdroj: Nutrients, Vol 13, Iss 1321, p 1321 (2021)
Nutrients
Volume 13
Issue 4
ISSN: 2072-6643
Popis: The main objective of this research was to carry out an experimental study, triple-blind, on the possible immunophysiological effects of a nutritional supplement (synbiotic, Gasteel Plus®, Heel España S.A.U.), containing a mixture of probiotic strains, such as Bifidobacterium lactis CBP-001010, Lactobacillus rhamnosus CNCM I-4036, and Bifidobacterium longum ES1, as well as the prebiotic fructooligosaccharides, on both professional athletes and sedentary people. The effects on some inflammatory/immune (IL-1β, IL-10, and immunoglobulin A) and stress (epinephrine, norepinephrine, dopamine, serotonin, corticotropin-releasing hormone (CRH), Adrenocorticotropic hormone (ACTH), and cortisol) biomarkers were evaluated, determined by flow cytometer and ELISA. The effects on metabolic profile and physical activity, as well as on various parameters that could affect physical and mental health, were also evaluated via the use of accelerometry and validated questionnaires. The participants were professional soccer players in the Second Division B of the Spanish League and sedentary students of the same sex and age range. Both study groups were randomly divided into two groups: a control group—administered with placebo, and an experimental group—administered with the synbiotic. Each participant was evaluated at baseline, as well as after the intervention, which lasted one month. Only in the athlete group did the synbiotic intervention clearly improve objective physical activity and sleep quality, as well as perceived general health, stress, and anxiety levels. Furthermore, the synbiotic induced an immunophysiological bioregulatory effect, depending on the basal situation of each experimental group, particularly in the systemic levels of IL-1β (increased significantly only in the sedentary group), CRH (decreased significantly only in the sedentary group), and dopamine (increased significantly only in the athlete group). There were no significant differences between groups in the levels of immunoglobulin A or in the metabolic profile as a result of the intervention. It is concluded that synbiotic nutritional supplements can improve anxiety, stress, and sleep quality, particularly in sportspeople, which appears to be linked to an improved immuno-neuroendocrine response in which IL-1β, CRH, and dopamine are clearly involved.
Databáze: OpenAIRE
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