Cadmium concentrations in human renal cortex tissue (Necropsies)
| Autor: | G. González, López-Artíguez M, Ana M. Cameán, Manuel Repetto |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Aging Kidney Cortex Adolescent Health Toxicology and Mutagenesis Renal cortex chemistry.chemical_element Physiology Biology Toxicology medicine Animals Humans Toxicokinetics Ecotoxicology Tissue Distribution Child Aged Trophic level Aged 80 and over Cadmium Kidney Spectrophotometry Atomic Infant Spectrometry X-Ray Emission Outbreak Environmental Exposure General Medicine Middle Aged Reference Standards Contamination Pollution medicine.anatomical_structure Liver chemistry Spain Child Preschool Cattle Female |
| Zdroj: | Bulletin of Environmental Contamination and Toxicology. 54 |
| ISSN: | 1432-0800 0007-4861 |
| DOI: | 10.1007/bf00197968 |
| Popis: | Cadmium is toxic to most living organisms. It occurs as part of different types of rocks, sedimentation sludges, coals and mineral oils; in minerals, cadmium (Cd) is frequently associated with zinc. Its world wide presence and considerable industrial use has given rise to an increase in its content in trophic food chains, which contribute mainly to human exposure. Oral absorption is relatively low and is influenced by the solubility of the compound, type of diet, and individual nutritional state. Interest in Cd contamination began after the outbreak of itai-itai disease in Japan. Evaluation of Cd contamination has been carried out in all the countries of the European Economic Community, and it has been estimated that in Spain emissions to the atmosphere and water are respectively 6.89 and 3.79% of total emissions in the European Communities. After exposure, the kidney is the organ which contains the highest concentrations of the Cd and retains it longest. When critical body concentration is reached, renal malfunction and damage are produced. Moreover, studies on humans not occupationally exposed to Cd show 50% of the body burden is found in the kidneys. Cd in the renal cortex increases with age, reaching a maximum between 40-60 years.more » Differences found among populations have been associated with daily intake in the diet and smoking habits. Taking into consideration the lack of studies on factors influencing the Cd burden in renal cortex in our country, the aim of the present paper was to find out the levels of Cd in renal cortex samples obtained from necropsies of inhabitants of Andalusia, Spain, and compare them with levels in other populations not occupationally exposed to the element; also to investigate the influence of individual factors, such as sex, age and drug addition on said Cd levels. 21 refs., 1 fig., 2 tabs.« less |
| Databáze: | OpenAIRE |
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