Synthesis and chemical behaviour of 17α-butyl-3β,17β-dihydroxy-16-oximino-5-androstene

Autor:	Katarina Penov-Gaši, Ljubica Medić-Mijačević, Srdjan Stojanović, Dora Molnar-Gabor, Marija N. Sakač
Rok vydání:	2001
Předmět:	lcsh:Chemistry lcsh:QD1-999 Chemistry General Chemistry 17-aza-d-homo derivatives of androstene beckmann fragmentation
Zdroj:	Journal of the Serbian Chemical Society, Vol 66, Iss 1, Pp 23-26 (2001)
ISSN:	1820-7421 0352-5139
DOI:	10.2298/jsc0101023s
Popis:	Starting from 3 -hydroxy-16-oximino-5-androsten-17-one (1), the recently synthesized 16-oximino-17 -hydroxy-17 -butyl derivative 2 gave by the Beckmann fragmentation reactionwith titanium(III) chloride or p-toluenesulphonyl chloride the corresponding D-seco derivative 3. However, using acetic anhydride, in addition to the 3 -acetoxy D-seco derivative 4, the 17-aza D-homo derivative 5 was obtained. The structure of compound 5 was proposed on the basis of NMR-spectroscopy.
Databáze:	OpenAIRE
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