Pressure Point Thresholds and ME/CFS Comorbidity as Indicators of Patient’s Response to Manual Physiotherapy in Fibromyalgia
| Autor: | Elisa Oltra, Francisco Javier Falaguera-Vera, Mario Zacarés, Javier Bonastre-Férez, María Garcia-Escudero |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Fibromyalgia Health Toxicology and Mutagenesis lcsh:Medicine Comorbidity 03 medical and health sciences 0302 clinical medicine Quality of life (healthcare) medicine Humans 030212 general & internal medicine physiotherapy Physical Therapy Modalities Polypharmacy pressure point threshold (PPT) Fatigue Syndrome Chronic business.industry manual therapy (MT) Communication lcsh:R Public Health Environmental and Occupational Health medicine.disease Clinical trial Allodynia Physical therapy Quality of Life Integrative medicine medicine.symptom Manual therapy business myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health, Vol 17, Iss 8044, p 8044 (2020) |
| ISSN: | 1660-4601 1661-7827 |
| Popis: | Current pharmacological treatments of Fibromyalgia (FM) are merely symptom palliative, as clinical trials have so far failed to provide overall benefits without associated harms. Polypharmacy often leads to patient’s health deterioration and chronic drug use to an eventual lack of patient’s response. Emerging evidence supports that physiotherapy treatments based on mechanical triggers improve FM symptoms and therefore could be used for therapeutic purposes by themselves or in combination with current pharmacological treatments, as part of integrative medicine programs. However, a paucity of studies rigorously and systematically evaluating this possibility exists. This study uses scores from validated standardized questionnaires, algometer pressure point threshold (PPT) readings and responses from a custom self-developed questionnaire to determine the impact of a pressure-controlled custom manual protocol on FM hyperalgesia/allodynia, fatigue and patient’s quality of life. The results show that patient’s baseline sensitivity to pain inversely correlates with treatment response in FM. Moreover, post-stratification analysis unexpectedly reveals that patients presenting comorbid ME/CFS do not seem to respond to the applied therapy as those presenting FM only. Therefore, pre-treatment PPTs and ME/CFS comorbidity may serve as indicators to predict patient’s response to physiotherapy programs based on mechanical triggers. Further exploration of these findings is granted. In addition, the study of gene expression profiles in the blood collection generated by this study should help unveil the molecular mechanisms behind patient’s differential response to manual therapy. |
| Databáze: | OpenAIRE |
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