Co-expression of xenopsin and rhabdomeric opsin in photoreceptors bearing microvilli and cilia
| Autor: | Ioannis Kourtesis, Sharat Chandra Tumu, Harald Hausen, Oliver Vöcking |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Opsin genetic structures Leptochiton asellus Xenopus Proteins Photoreceptor cell opsin Biology (General) biology General Neuroscience Cilium digestive oral and skin physiology Vertebrate General Medicine Anatomy eye Cell biology medicine.anatomical_structure Genomics and Evolutionary Biology Larva Medicine Protostome Insight Metabolic Networks and Pathways QH301-705.5 Science General Biochemistry Genetics and Molecular Biology 03 medical and health sciences biology.animal evolution medicine Animals Photoreceptor Cells Gene Opsins General Immunology and Microbiology Transporter equipment and supplies invertebrates biology.organism_classification photoreceptor eye diseases 030104 developmental biology Mollusca Other sense organs Peptides Function (biology) Neuroscience |
| Zdroj: | eLife, Vol 6 (2017) eLife |
| ISSN: | 2050-084X |
| Popis: | Ciliary and rhabdomeric opsins are employed by different kinds of photoreceptor cells, such as ciliary vertebrate rods and cones or protostome microvillar eye photoreceptors, that have specialized structures and molecular physiologies. We report unprecedented cellular co-expression of rhabdomeric opsin and a visual pigment of the recently described xenopsins in larval eyes of a mollusk. The photoreceptors bear both microvilli and cilia and express proteins that are orthologous to transporters in microvillar and ciliary opsin trafficking. Highly conserved but distinct gene structures suggest that xenopsins and ciliary opsins are of independent origin, irrespective of their mutually exclusive distribution in animals. Furthermore, we propose that frequent opsin gene loss had a large influence on the evolution, organization and function of brain and eye photoreceptor cells in bilaterian animals. The presence of xenopsin in eyes of even different design might be due to a common origin and initial employment of this protein in a highly plastic photoreceptor cell type of mixed microvillar/ciliary organization. |
| Databáze: | OpenAIRE |
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