Effect of Combination Therapy of Hydroxychloroquine and Azithromycin on Mortality in Patients With COVID-19
| Autor: | Daniele Pastori, Giovanbattista Ippoliti, Francesco Scaglione, Gianluca Perseghin, Arianna Pani, Stefano Milighetti, Paolo Grosso, Marinella Lauriola, Marjieh Mazen, Andrea Mortara |
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| Přispěvatelé: | Lauriola, M, Pani, A, Ippoliti, G, Mortara, A, Milighetti, S, Mazen, M, Perseghin, G, Pastori, D, Grosso, P, Scaglione, F |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
030213 general clinical medicine medicine.medical_specialty medicine.medical_treatment Azithromycin 030226 pharmacology & pharmacy Gastroenterology Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Hospital Mortality General Pharmacology Toxicology and Pharmaceutics Aged Retrospective Studies Aged 80 and over Mechanical ventilation SARS-CoV-2 business.industry Research General Neuroscience Hazard ratio COVID-19 Retrospective cohort study Hydroxychloroquine Articles General Medicine Middle Aged mortality Confidence interval COVID-19 Drug Treatment Log-rank test hydroxychloroquine azithromycin Drug Therapy Combination Female business Cohort study medicine.drug |
| Zdroj: | Clinical and Translational Science |
| Popis: | Conflicting evidence regarding the use of hydroxychloroquine (HCQ) and azithromycin for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection do exist. We performed a retrospective single‐center cohort study including 377 consecutive patients admitted for pneumonia related to coronavirus disease 2019 (COVID‐19). Of these, 297 were in combination treatment, 17 were on HCQ alone, and 63 did not receive either of these 2 drugs because of contraindications. The primary end point was in‐hospital death. Mean age was 71.8 ± 13.4 years and 34.2% were women. We recorded 146 deaths: 35 in no treatment, 7 in HCQ treatment group, and 102 in HCQ + azithromycin treatment group (log rank test for Kaplan–Meier curve P |
| Databáze: | OpenAIRE |
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