Resident Neural Stem Cells Restrict Tissue Damage and Neuronal Loss After Spinal Cord Injury in Mice
| Autor: | Jonas Frisén, Pedro Réu, Moa Stenudd, Sofia Zdunek, Peter Damberg, Hanna Sabelström, Marta Elfineh, David O. Dias, Christian Göritz |
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| Rok vydání: | 2013 |
| Předmět: |
Cell Survival
Central nervous system Axonal loss Apoptosis Glial scar Lesion Cicatrix Mice Neural Stem Cells medicine Animals Spinal cord injury Spinal Cord Injuries Multidisciplinary biology Forkhead Transcription Factors Anatomy medicine.disease Spinal cord Axons Mice Mutant Strains Neural stem cell Genes ras medicine.anatomical_structure Astrocytes biology.protein medicine.symptom Neuroscience Neurotrophin |
| Zdroj: | Science. 342:637-640 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.1242576 |
| Popis: | The Good Scar We tend to think of scars as bad and, in the central nervous system, as counterproductive to recovery. Studying mice, Sabelström et al. (p. 637 ) prevented resident stem cells from proliferating after spinal cord injury. Without the astrocytes generated by the neural stem cells, recovery from spinal cord lesions was poorer than normal. Thus, somewhat counterintuitively, glial scarring appears to limit spinal cord damage and support the remaining cells. |
| Databáze: | OpenAIRE |
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