The myth of pulmonary Raynaud's phenomenon: the contribution of pulmonary arterial vasospasm in patients with systemic sclerosis related pulmonary arterial hypertension
| Autor: | D Mukerjee, JG Coghlan, K Howells, L B Yap, Christopher P. Denton, Voon H Ong, Carol M. Black |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Cardiac Catheterization Spasm medicine.medical_specialty Cardiac output genetic structures Hypertension Pulmonary Immunology Pilot Projects Pulmonary Artery General Biochemistry Genetics and Molecular Biology Rheumatology medicine.artery Internal medicine medicine Humans Immunology and Allergy Prospective Studies Cardiac Output Scleroderma Systemic Lung business.industry Respiratory disease Hemodynamics Cold pressor test Vasospasm Middle Aged medicine.disease Pulmonary hypertension Surgery Cold Temperature Extended Report medicine.anatomical_structure Pulmonary artery cardiovascular system Cardiology Vascular resistance Female Vascular Resistance Endothelium Vascular business |
| Zdroj: | Annals of the Rheumatic Diseases. 63:1627-1631 |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.2003.015289 |
| Popis: | Objective: To investigate the contribution of cold induced pulmonary vasospasm by peripheral and central cold stimulus in exacerbating pulmonary arterial hypertension (PAH) in patients with systemic sclerosis undergoing cardiac catheterisation. Methods: In a prospective pilot study, 21 patients with systemic sclerosis and catheter proven PAH had mean pulmonary artery pressure (mPAP), pulmonary vascular resistance (PVR), and cardiac output (CO) measured before and after peripheral (hand immersion into cold water at 10–15°C for two minutes if tolerated) and central (direct cold water at 4°C injected into the right atrium) cold pressor challenge. Markers of endothelial activation, platelet function, and nitric oxide degradation were measured in blood sampled from the pulmonary artery. Results: 19 of the patients (mean (SD) age, 56 (4) years; baseline mPAP, 34 (8) mm Hg; PVR, 420 (87) dyne.s.cm–5; CO, 6.4 (1.8) l/min) tolerated cold hand immersion for the maximum two minute duration. All 21 tolerated central cold pressor challenge (three to five injections of 10 ml saline boluses at 4°C). There was no significant change in haemodynamics after cold challenge by either route of provocation. Levels of endothelin-1, von Willebrand factor, fibrinogen, and 3-nitrotyrosine were raised compared with control values in patients with systemic sclerosis but without PAH, but did not change significantly after peripheral cold challenge. Conclusions: Pulmonary vasospasm in response to peripheral and centrally administered cold pressor challenge is unlikely to contribute to persistence of pulmonary arterial hypertension in patients with systemic sclerosis. |
| Databáze: | OpenAIRE |
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