Interleukin‐33 polymorphisms and serum concentrations in mycosis fungoides
| Autor: | Anna Kowalczyk, Monika Zabłotna, Wojciech Rogowski, Katarzyna Czajkowska, Krzysztof Rębała, Alicja Rustowska-Rogowska, Jolanta Gleń, Małgorzata Sokołowska-Wojdyło, Roman Nowicki, Tomasz Jarząbek |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Skin Neoplasms Single-nucleotide polymorphism Inflammation Dermatology Polymorphism Single Nucleotide Proinflammatory cytokine 030207 dermatology & venereal diseases 03 medical and health sciences Mycosis Fungoides 0302 clinical medicine Internal medicine medicine Humans SNP Receptor Mycosis fungoides business.industry Middle Aged Serum concentration Interleukin-33 medicine.disease Interleukin-1 Receptor-Like 1 Protein Interleukin 33 Endocrinology 030220 oncology & carcinogenesis Female medicine.symptom business |
| Zdroj: | International Journal of Dermatology. 59:345-351 |
| ISSN: | 1365-4632 0011-9059 |
| Popis: | BACKGROUND Mycosis fungoides (MF) skin lesions are characterized by low-grade inflammation, which may be sustained by proinflammatory cytokines as probably interleukin-33 (IL-33). We compared serum concentrations of IL-33 and its receptor ST2 and the frequency of selected IL-33 single nucleotide polymorphisms (SNPs) between patients with MF and healthy controls. METHODS In 88 patients with MF and 66 healthy controls, we analyzed SNPs in the 9894 and 11877 loci of the IL-33 gene. Moreover, we measured serum concentrations of IL-33 and its receptor ST2. RESULTS There were no statistically significant differences in the frequencies of both IL-33 SNPs between patients and controls. Compared with controls, patients with MF had similar IL-33 serum concentrations (P = 0.71) but significantly increased ST2 concentrations (P |
| Databáze: | OpenAIRE |
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